Gene Symbol | MPRIP |
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Entrez Gene | 23164 |
Alt Symbol | M-RIP, MRIP, RHOIP3, RIP3, p116Rip |
Species | Human |
Gene Type | protein-coding |
Description | myosin phosphatase Rho interacting protein |
Other Description | Rho interacting protein 3|myosin phosphatase Rho-interacting protein |
Swissprots | Q6WCQ1 Q6DHW2 Q3KQZ5 Q8N390 Q7Z5Y2 Q5FB94 Q96G40 |
Accessions | CDI70968 EAW55721 EAW55722 EAW55723 EAW55724 Q6WCQ1 AB020671 BAA74887 AB098507 BAC78198 AB189741 BAD89507 AB362572 BAF81537 AB362573 BAF81538 AJ844625 CAH59751 AK025229 AK025604 AK026035 AK091337 AK092287 BAC03851 AL834513 CAD39169 AY296247 AAQ63176 BC009982 AAH09982 BC012426 AAH12426 BC014102 BC021058 BC021070 BC030255 BC050323 BC063588 BC075847 AAH75847 BC105987 AAI05988 BC136479 AAI36480 BE048871 BU527795 CF126021 D23673 DQ582316 DQ598455 XM_005256563 XP_005256620 XM_005256564 XP_005256621 XM_011523761 XP_011522063 XM_011523762 XP_011522064 XM_011523763 XP_011522065 XM_011523764 XP_011522066 XM_011523765 XP_011522067 XM_011523766 XP_011522068 XM_011523767 XP_011522069 NM_015134 NP_055949 NM_201274 NP_958431 |
Function | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14506264, ECO:0000269|PubMed:16257966}. Note=Colocalizes with F-actin. |
M-RIP (D8G8R) Rabbit mAb - 14396 from Cell Signaling Technology
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M-RIP (D9I5T) Rabbit mAb - 14383 from Cell Signaling Technology
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M-RIP Antibody - 11949 from Cell Signaling Technology
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RIP3 (H-43) - sc-135170 from Santa Cruz Biotechnology
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M-RIP (C-14) - sc-135494 from Santa Cruz Biotechnology
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M-RIP (D-13) - sc-135495 from Santa Cruz Biotechnology
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Anti-MPRIP antibody - ab167042 from Abcam
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Anti-MPRIP antibody - ab111381 from Abcam
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Anti-MPRIP antibody - ab171032 from Abcam
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Anti-MPRIP / RIP3 Antibody (Glu785) - LS-C193177 from LifeSpan Bioscience
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Anti-MPRIP / RIP3 Antibody - LS-C335103 from LifeSpan Bioscience
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Anti-MPRIP / RIP3 Antibody (aa771-820) - LS-C170287 from LifeSpan Bioscience
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Anti-MPRIP / RIP3 Antibody (aa723-772) IHC-plus⢠- LS-B8567 from LifeSpan Bioscience
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MPRIP Antibody - NBP1-81035 from Novus Biologicals
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MPRIP Antibody - NBP1-81036 from Novus Biologicals
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Anti-MPRIP antibody produced in rabbit - HPA022901 from Sigma-Aldrich
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Anti-MPRIP antibody produced in rabbit - HPA022034 from Sigma-Aldrich
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Anti-MPRIP antibody produced in rabbit - SAB4500953 from Sigma-Aldrich
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MPRIP antibody - GTX87982 from GeneTex
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MPRIP Antibody (OAAF03863) - OAAF03863 from Aviva Systems Biology
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MPRIP Antibody (OAAF04629) - OAAF04629 from Aviva Systems Biology
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Anti -M-RIP (Mprip, MPRIP, Myosin Phosphatase Rho-interacting Protein, p116Rip,Rho-interacting Protein 3, Rhoip3, RIP3, RP23-180B18.4) - 223978 from USBiological Life Science
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MPRIP Polyclonal Antibody - A0666 from ABclonal
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RIP3 antibody (PE-Cy5) - orb130120 from Biorbyt
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RIP3 antibody (Cy3) - orb114832 from Biorbyt
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