| Gene Symbol | MPRIP |
|---|---|
| Entrez Gene | 23164 |
| Alt Symbol | M-RIP, MRIP, RHOIP3, RIP3, p116Rip |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin phosphatase Rho interacting protein |
| Other Description | Rho interacting protein 3|myosin phosphatase Rho-interacting protein |
| Swissprots | Q6WCQ1 Q6DHW2 Q3KQZ5 Q8N390 Q7Z5Y2 Q5FB94 Q96G40 |
| Accessions | CDI70968 EAW55721 EAW55722 EAW55723 EAW55724 Q6WCQ1 AB020671 BAA74887 AB098507 BAC78198 AB189741 BAD89507 AB362572 BAF81537 AB362573 BAF81538 AJ844625 CAH59751 AK025229 AK025604 AK026035 AK091337 AK092287 BAC03851 AL834513 CAD39169 AY296247 AAQ63176 BC009982 AAH09982 BC012426 AAH12426 BC014102 BC021058 BC021070 BC030255 BC050323 BC063588 BC075847 AAH75847 BC105987 AAI05988 BC136479 AAI36480 BE048871 BU527795 CF126021 D23673 DQ582316 DQ598455 XM_005256563 XP_005256620 XM_005256564 XP_005256621 XM_011523761 XP_011522063 XM_011523762 XP_011522064 XM_011523763 XP_011522065 XM_011523764 XP_011522066 XM_011523765 XP_011522067 XM_011523766 XP_011522068 XM_011523767 XP_011522069 NM_015134 NP_055949 NM_201274 NP_958431 |
| Function | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14506264, ECO:0000269|PubMed:16257966}. Note=Colocalizes with F-actin. |
M-RIP CRISPR/Cas9 KO Plasmid (h) - sc-411682 from Santa Cruz Biotechnology
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M-RIP HDR Plasmid (h) - sc-411682-HDR from Santa Cruz Biotechnology
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M-RIP Double Nickase Plasmid (h) - sc-411682-NIC from Santa Cruz Biotechnology
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M-RIP Double Nickase Plasmid (h2) - sc-411682-NIC-2 from Santa Cruz Biotechnology
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M-RIP CRISPR Activation Plasmid (h) - sc-411682-ACT from Santa Cruz Biotechnology
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M-RIP CRISPR Activation Plasmid (h2) - sc-411682-ACT-2 from Santa Cruz Biotechnology
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M-RIP Lentiviral Activation Particles (h) - sc-411682-LAC from Santa Cruz Biotechnology
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M-RIP Lentiviral Activation Particles (h2) - sc-411682-LAC-2 from Santa Cruz Biotechnology
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M-RIP siRNA (h) - sc-93832 from Santa Cruz Biotechnology
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M-RIP shRNA Plasmid (h) - sc-93832-SH from Santa Cruz Biotechnology
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M-RIP shRNA (h) Lentiviral Particles - sc-93832-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU102041 from Sigma-Aldrich
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MISSION® esiRNA - EHU141181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14512 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14512 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06067 from Sigma-Aldrich
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MPRIP siRNA (Human) - CRH8047 from Cohesion Biosciences
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Human MPRIP siRNA - orb268549 from Biorbyt
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MPRIP shRNA Plasmid (Human) - CHH8047 from Cohesion Biosciences
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MPRIP miRNA 3'UTR clone - MiUTR3H-12691 from Creative biogene
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MPRIP miRNA 3'UTR clone - MiUTR3H-12692 from Creative biogene
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