PHACTR4

Gene Symbol	PHACTR4
Entrez Gene	65979
Alt Symbol	PPP1R124
Species	Human
Gene Type	protein-coding
Description	phosphatase and actin regulator 4
Other Description	protein phosphatase 1, regulatory subunit 124
Swissprots	Q6NUN6 Q8N384 A2APK6 Q9H8W6 Q8IZ21 B9ZVW0 Q9H395 D3DPM3 Q68DD4 Q9H6X0
Accessions	CBX47623 CBX47624 EAX07696 EAX07697 EAX07698 Q8IZ21 AA973468 AF130081 AAG35507 AK023233 BAB14483 AK024663 AK025436 BAB15130 AL705720 BC016152 BC021247 AAH21247 BC029266 AAH29266 BC068508 AAH68508 CR749449 CAH18286 DA586663 JF432272 ADZ15489 XM_005245970 XP_005246027 XM_006710842 XP_006710905 XM_006710843 XP_006710906 XM_006710844 XP_006710907 XM_006710845 XP_006710908 XM_006710846 XP_006710909 XM_006710847 XP_006710910 XM_006710848 XP_006710911 XM_006710850 XP_006710913 XM_006710851 XP_006710914 XM_006710852 XP_006710915 XM_011542028 XP_011540330 XM_011542029 XP_011540331 XM_011542030 XP_011540332 XM_011542031 XP_011540333 NM_023923 NP_076412 NM_001048183 NP_001041648
Function	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PHACTR4-Over-expression-Lysate - LY15089a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PHACTR4 overexpression lysate - LY411450 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PHACTR4 overexpression lysate - LY420773 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PHACTR4 293 Cell Lysate - 405753 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PHACTR4 293 Cell Lysate - 409446 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PHACTR4 Overexpression Lysate (Native) - NBL1-14346 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PHACTR4 Overexpression Lysate (Native) - NBL1-14347 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PHACTR4 Over-expression Lysate Product - GWB-9B63B7 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

PHACTR4 Over-expression Lysate Product - GWB-83E145 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human PHACTR4 Knockdown Stable Cell Line - CSC-DC011676 from Creative biogene Category Cell Line Species Human

Search more