PHACTR4

Gene Symbol PHACTR4
Entrez Gene 65979
Alt Symbol PPP1R124
Species Human
Gene Type protein-coding
Description phosphatase and actin regulator 4
Other Description protein phosphatase 1, regulatory subunit 124
Swissprots Q6NUN6 Q8N384 A2APK6 Q9H8W6 Q8IZ21 B9ZVW0 Q9H395 D3DPM3 Q68DD4 Q9H6X0
Accessions CBX47623 CBX47624 EAX07696 EAX07697 EAX07698 Q8IZ21 AA973468 AF130081 AAG35507 AK023233 BAB14483 AK024663 AK025436 BAB15130 AL705720 BC016152 BC021247 AAH21247 BC029266 AAH29266 BC068508 AAH68508 CR749449 CAH18286 DA586663 JF432272 ADZ15489 XM_005245970 XP_005246027 XM_006710842 XP_006710905 XM_006710843 XP_006710906 XM_006710844 XP_006710907 XM_006710845 XP_006710908 XM_006710846 XP_006710909 XM_006710847 XP_006710910 XM_006710848 XP_006710911 XM_006710850 XP_006710913 XM_006710851 XP_006710914 XM_006710852 XP_006710915 XM_011542028 XP_011540330 XM_011542029 XP_011540331 XM_011542030 XP_011540332 XM_011542031 XP_011540333 NM_023923 NP_076412 NM_001048183 NP_001041648
Function Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.

Human PHACTR4 full length protein - ab163937 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163937 on a 12.5% SDS-PAGE stained with Coomassie Blue.

PHACTR4 Antibody Blocking Peptide - LS-E10385 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human PHACTR4 Protein - H00065979-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

PHAR4-Antibody-C-term-Blocking-Peptide - BP9904b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

PHACTR4 - H00065979-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

PHACTR4 fusion protein - Ag4054 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human PHACTR4, GST-tagged - PHACTR4-1672H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Phosphatase and actin regulator 4(PHACTR4) - CSB-YP017883HU CSB-EP017883HU CSB-BP017883HU CSB-MP017883HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Phosphatase and actin regulator 4 (PHACTR4), Recombinant Protein - MBS1363016 from MyBioSource

Category Protein
Prices $1,510.00, $1,510.00, $1,735.00, $1,735.00, $2,580.00, $2,580.00, $3,025.00, $3,025.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

PHACTR4 Recombinant Protein Antigen - NBP1-82267PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

PHACTR4 Peptide, Human - M34GP11676H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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