| Gene Symbol | PHACTR4 |
|---|---|
| Entrez Gene | 65979 |
| Alt Symbol | PPP1R124 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatase and actin regulator 4 |
| Other Description | protein phosphatase 1, regulatory subunit 124 |
| Swissprots | Q6NUN6 Q8N384 A2APK6 Q9H8W6 Q8IZ21 B9ZVW0 Q9H395 D3DPM3 Q68DD4 Q9H6X0 |
| Accessions | CBX47623 CBX47624 EAX07696 EAX07697 EAX07698 Q8IZ21 AA973468 AF130081 AAG35507 AK023233 BAB14483 AK024663 AK025436 BAB15130 AL705720 BC016152 BC021247 AAH21247 BC029266 AAH29266 BC068508 AAH68508 CR749449 CAH18286 DA586663 JF432272 ADZ15489 XM_005245970 XP_005246027 XM_006710842 XP_006710905 XM_006710843 XP_006710906 XM_006710844 XP_006710907 XM_006710845 XP_006710908 XM_006710846 XP_006710909 XM_006710847 XP_006710910 XM_006710848 XP_006710911 XM_006710850 XP_006710913 XM_006710851 XP_006710914 XM_006710852 XP_006710915 XM_011542028 XP_011540330 XM_011542029 XP_011540331 XM_011542030 XP_011540332 XM_011542031 XP_011540333 NM_023923 NP_076412 NM_001048183 NP_001041648 |
| Function | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. |
PHACTR4 CRISPR/Cas9 KO Plasmid (h) - sc-409318 from Santa Cruz Biotechnology
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PHACTR4 HDR Plasmid (h) - sc-409318-HDR from Santa Cruz Biotechnology
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PHACTR4 Double Nickase Plasmid (h) - sc-409318-NIC from Santa Cruz Biotechnology
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PHACTR4 Double Nickase Plasmid (h2) - sc-409318-NIC-2 from Santa Cruz Biotechnology
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PHACTR4 CRISPR Activation Plasmid (h) - sc-409318-ACT from Santa Cruz Biotechnology
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PHACTR4 CRISPR Activation Plasmid (h2) - sc-409318-ACT-2 from Santa Cruz Biotechnology
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PHACTR4 Lentiviral Activation Particles (h) - sc-409318-LAC from Santa Cruz Biotechnology
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PHACTR4 Lentiviral Activation Particles (h2) - sc-409318-LAC-2 from Santa Cruz Biotechnology
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PHACTR4 siRNA (h) - sc-88147 from Santa Cruz Biotechnology
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PHACTR4 shRNA Plasmid (h) - sc-88147-SH from Santa Cruz Biotechnology
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PHACTR4 shRNA (h) Lentiviral Particles - sc-88147-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU103001 from Sigma-Aldrich
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MISSION® esiRNA - EHU117621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16707 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16707 from Sigma-Aldrich
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PHACTR4 siRNA (Human) - CRJ2207 from Cohesion Biosciences
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shRNA set against Human PHACTR4 (NM_023923.3) - SHH374504 from Creative biogene
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shRNA set against Human PHACTR4(NM_001048183.1) - SHR110274 from Creative biogene
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shRNA set against Human PHACTR4(NM_023923.3) - SHR110310 from Creative biogene
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Human PHACTR4 siRNA - orb272708 from Biorbyt
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PHACTR4 shRNA Plasmid (Human) - CHJ2207 from Cohesion Biosciences
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PHACTR4 miRNA 3'UTR clone - MiUTR1H-07838 from Creative biogene
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PHACTR4 miRNA 3'UTR clone - MiUTR1H-07839 from Creative biogene
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