| Gene Symbol |
ELAC2
|
| Entrez Gene |
60528
|
| Alt Symbol |
COXPD17, ELC2, HPC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
elaC ribonuclease Z 2
|
| Other Description |
RNase Z 2|elaC homolog 2|elaC homolog protein 2|heredity prostate cancer protein 2|putative prostate cancer susceptibility protein HPC2/ELAC2|ribonuclease Z 2|tRNA 3 endonuclease 2|tRNase Z (long form)|tRNase Z 2|zinc phosphodiesterase ELAC protein 2
|
| Swissprots |
Q9NVT1 Q9BQ52 Q9HAS8 Q6IA94 B4DPL9 Q9HAS9
|
| Accessions |
AAG24439 AAG24440 EAW89961 EAW89962 EAW89963 EAW89964 Q9BQ52 AA706335 AF304370 AAG24441 AK001392 AK074244 AK094012 AK094333 BAG52861 AK094687 BAG52912 AK124838 BAC85964 AK125030 BAC86026 AK298397 BAG60631 AK300011 BAG61827 AK304589 BAG65377 BC001939 AAH01939 BC004158 AAH04158 BC046924 CB241821 CR457261 CAG33542 DB455960 DC394013 DC411088 JF432300 ADZ15517 NM_001165962 NP_001159434 NM_018127 NP_060597 NM_173717 NP_776065
|
| Function |
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. {ECO:0000269|PubMed:21593607}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:21593607}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly mitochondrial.
|
| Tissue Specificity |
Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. {ECO:0000269|PubMed:11175785}.
|
| Top Pathways |
RNA transport
|
![Western Blot: ELAC2 Overexpression Lysate (Adult Normal) [NBL1-10223] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ELAC2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7638_ELAC2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10223-img0002.jpg)