Gene Symbol | ELAC2 |
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Entrez Gene | 60528 |
Alt Symbol | COXPD17, ELC2, HPC2 |
Species | Human |
Gene Type | protein-coding |
Description | elaC ribonuclease Z 2 |
Other Description | RNase Z 2|elaC homolog 2|elaC homolog protein 2|heredity prostate cancer protein 2|putative prostate cancer susceptibility protein HPC2/ELAC2|ribonuclease Z 2|tRNA 3 endonuclease 2|tRNase Z (long form)|tRNase Z 2|zinc phosphodiesterase ELAC protein 2 |
Swissprots | Q9NVT1 Q9BQ52 Q9HAS8 Q6IA94 B4DPL9 Q9HAS9 |
Accessions | AAG24439 AAG24440 EAW89961 EAW89962 EAW89963 EAW89964 Q9BQ52 AA706335 AF304370 AAG24441 AK001392 AK074244 AK094012 AK094333 BAG52861 AK094687 BAG52912 AK124838 BAC85964 AK125030 BAC86026 AK298397 BAG60631 AK300011 BAG61827 AK304589 BAG65377 BC001939 AAH01939 BC004158 AAH04158 BC046924 CB241821 CR457261 CAG33542 DB455960 DC394013 DC411088 JF432300 ADZ15517 NM_001165962 NP_001159434 NM_018127 NP_060597 NM_173717 NP_776065 |
Function | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. {ECO:0000269|PubMed:21593607}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:21593607}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly mitochondrial. |
Tissue Specificity | Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. {ECO:0000269|PubMed:11175785}. |
Top Pathways | RNA transport |
ELAC2 CRISPR/Cas9 KO Plasmid (h) - sc-412943 from Santa Cruz Biotechnology
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ELAC2 HDR Plasmid (h) - sc-412943-HDR from Santa Cruz Biotechnology
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ELAC2 Double Nickase Plasmid (h) - sc-412943-NIC from Santa Cruz Biotechnology
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ELAC2 Double Nickase Plasmid (h2) - sc-412943-NIC-2 from Santa Cruz Biotechnology
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ELAC2 CRISPR Activation Plasmid (h) - sc-412943-ACT from Santa Cruz Biotechnology
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ELAC2 CRISPR Activation Plasmid (h2) - sc-412943-ACT-2 from Santa Cruz Biotechnology
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ELAC2 Lentiviral Activation Particles (h) - sc-412943-LAC from Santa Cruz Biotechnology
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ELAC2 Lentiviral Activation Particles (h2) - sc-412943-LAC-2 from Santa Cruz Biotechnology
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ELAC2 siRNA (h) - sc-93846 from Santa Cruz Biotechnology
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ELAC2 shRNA Plasmid (h) - sc-93846-SH from Santa Cruz Biotechnology
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ELAC2 shRNA (h) Lentiviral Particles - sc-93846-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7794 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7794 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03276 from Sigma-Aldrich
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ELAC2 siRNA (Human) - CRJ1813 from Cohesion Biosciences
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ELAC2 - MBS829604 from MyBioSource
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shRNA set against Human ELAC2 (NM_018127.6) - SHH284925 from Creative biogene
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Human ELAC2 siRNA - orb272314 from Biorbyt
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ELAC2 shRNA Plasmid (Human) - CHJ1813 from Cohesion Biosciences
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ELAC2 miRNA 3'UTR clone - MiUTR3H-07609 from Creative biogene
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ELAC2 miRNA 3'UTR clone - MiUTR3H-07610 from Creative biogene
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ELAC2 miRNA 3'UTR clone - MiUTR3H-07611 from Creative biogene
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