Gene Symbol | WDR5 |
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Entrez Gene | 11091 |
Alt Symbol | BIG-3, CFAP89, SWD3 |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 5 |
Other Description | BMP2-induced 3-kb gene protein|SWD3, Set1c WD40 repeat protein, homolog|WD repeat-containing protein 5|WD-repeat protein 5|cilia and flagella associated protein 89 |
Swissprots | P61964 |
Accessions | CAD34861 EAW88117 EAW88118 EAW88119 EAW88120 P61964 AA490313 AJ011376 CAB66159 AK000552 BAA91248 AK024484 BAB15774 AK025810 BC001635 AAH01635 BC015594 BC029769 BG773451 HQ448239 ADQ32719 XM_005272163 XP_005272220 NM_017588 NP_060058 NM_052821 NP_438172 |
Function | Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. {ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20018852}. |
Human WDR5 full length protein - ab98079 from Abcam
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Human WDR5 full length protein - ab198462 from Abcam
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Human WDR5 full length protein - ab117194 from Abcam
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Human WDR5 peptide - ab24388 from Abcam
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WDR5 Antibody Blocking Peptide - LS-E3928 from LifeSpan Bioscience
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WDR5 Antibody Blocking Peptide - LS-E15192 from LifeSpan Bioscience
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WDR5 Antibody Blocking Peptide - LS-E15193 from LifeSpan Bioscience
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WDR5 Antibody Blocking Peptide - LS-E31266 from LifeSpan Bioscience
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WDR5 Recombinant Protein - H00011091-P01 from Novus Biologicals
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WDR5 Partial Recombinant Protein - H00011091-Q01 from Novus Biologicals
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Recombinant Human WDR5 Protein - NBP1-50848 from Novus Biologicals
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WDR5-Antibody-N-term-Blocking-Peptide - BP16126a from Abgent, a WuXi AppTec company
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WDR5 Protein (OPPA02395) - OPPA02395 from Aviva Systems Biology
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Human WDR5 protein - orb244629 from Biorbyt
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Human WDR5 protein - orb81474 from Biorbyt
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WDR5 Blocking Peptide - 33R-4768 from Fitzgerald
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WDR5 protein (His tag) - 80R-1394 from Fitzgerald
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WDR5 / BIG3 (1-334, His-tag) - AR09569PU-L from Acris Antibodies
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WDR5 / BIG3 (1-334, His-tag) - AR09569PU-N from Acris Antibodies
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WDR5 / BIG3 - H00011091-P01-10 from Acris Antibodies
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WDR5 / BIG3 - H00011091-P01-25 from Acris Antibodies
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WDR5 / BIG3 - H00011091-Q01-10 from Acris Antibodies
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WDR5 / BIG3 - H00011091-Q01-25 from Acris Antibodies
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WDR5 / BIG3 control peptide - AP10373CP-N from Acris Antibodies
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WDR5 / BIG3 (N-term) Control Peptide - AP55430CP-N from Acris Antibodies
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