Gene Symbol | WDR5 |
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Entrez Gene | 11091 |
Alt Symbol | BIG-3, CFAP89, SWD3 |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 5 |
Other Description | BMP2-induced 3-kb gene protein|SWD3, Set1c WD40 repeat protein, homolog|WD repeat-containing protein 5|WD-repeat protein 5|cilia and flagella associated protein 89 |
Swissprots | P61964 |
Accessions | CAD34861 EAW88117 EAW88118 EAW88119 EAW88120 P61964 AA490313 AJ011376 CAB66159 AK000552 BAA91248 AK024484 BAB15774 AK025810 BC001635 AAH01635 BC015594 BC029769 BG773451 HQ448239 ADQ32719 XM_005272163 XP_005272220 NM_017588 NP_060058 NM_052821 NP_438172 |
Function | Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. {ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20018852}. |
WDR5 (D3X5B) Rabbit mAb - 13073 from Cell Signaling Technology
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WDR5 (D9E1I) Rabbit mAb - 13105 from Cell Signaling Technology
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WDR5 (A-6) - sc-393116 from Santa Cruz Biotechnology
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WDR5 (G-9) - sc-393080 from Santa Cruz Biotechnology
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WDR5 (H-35) - sc-135245 from Santa Cruz Biotechnology
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WDR5/5B (C-15) - sc-47572 from Santa Cruz Biotechnology
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WDR5 (N-12) - sc-47575 from Santa Cruz Biotechnology
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WDR5 (SF-14) - sc-100895 from Santa Cruz Biotechnology
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WDR5/5B (K-16) - sc-47574 from Santa Cruz Biotechnology
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Anti-WDR5 antibody - ab187178 from Abcam
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Anti-WDR5 antibody [7B11] - ab104843 from Abcam
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Anti-WDR5 antibody [EPR11349(B)] - ab156012 from Abcam
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Anti-WDR5 antibody [EPR11350] - C-terminal - ab178410 from Abcam
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Anti-WDR5 antibody - ChIP Grade - ab56919 from Abcam
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Anti-WDR5 antibody - N-terminal - ab189932 from Abcam
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Anti-WDR5 antibody - N-terminal - ab176119 from Abcam
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Anti-WDR5 Antibody (N-Terminus) IHC-plus⢠- LS-B8824 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa1-120) - LS-C126475 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa12-40, AP) - LS-C224637 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa12-40, APC) - LS-C224638 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa12-40, FITC) - LS-C224640 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa12-40, Biotin) - LS-C224639 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa12-40, Azide-free, HRP) - LS-C224641 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa12-40, PE) - LS-C224642 from LifeSpan Bioscience
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Anti-WDR5 Antibody (aa11-40) - LS-C326339 from LifeSpan Bioscience
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