| Gene Symbol |
CNTN6
|
| Entrez Gene |
27255
|
| Alt Symbol |
NB3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
contactin 6
|
| Other Description |
contactin-6|neural adhesion molecule|neural recognition molecule NB-3
|
| Swissprots |
Q9UQ52 Q2KHM2
|
| Accessions |
CCO13711 EAW63871 EAW63872 Q9UQ52 AB003592 BAA82612 AK125798 AK294786 BAG57911 AK307814 AK314220 BC036338 BC113118 AAI13119 CN364480 DA094373 DA117077 DB170583 HG495391 XM_005265058 XP_005265115 XM_011533589 XP_011531891 XM_011533590 XP_011531892 XM_011533591 XP_011531893 XR_940415 NM_001289080 NP_001276009 NM_001289081 NP_001276010 NM_014461 NP_055276
|
| Function |
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
|
| Tissue Specificity |
Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
|