SLCO1B1

Gene Symbol SLCO1B1
Entrez Gene 10599
Alt Symbol HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6
Species Human
Gene Type protein-coding
Description solute carrier organic anion transporter family, member 1B1
Other Description OATP-2|liver-specific organic anion transporter 1|sodium-independent organic anion-transporting polypeptide 2|solute carrier family 21 (organic anion transporter), member 6|solute carrier family 21 member 6|solute carrier organic anion transporter family member 1B1
Swissprots Q9NQ37 Q9Y6L6 Q9UH89 Q9UBF3 Q29R64 B2R7G2
Accessions AAX20114 AFV58023 AFV58024 AFV58025 CAB97007 CAI38410 CAJ33680 CAX52185 EAW96420 EAW96421 Q9Y6L6 AB026257 BAA78639 AF060500 AAD38323 AF205071 AAF20212 AJ132573 CAB62577 AK312970 BAG35809 BC005243 BC020696 AAH20696 BC054878 AAH54878 BC070172 AAH70172 BC105596 AAI05597 BC114376 AAI14377 NM_006446 NP_006437
Function Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:22232210}.
Subcellular Location Basolateral cell membrane {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein {ECO:0000269|PubMed:12196548}. Note=Detected in basolateral membranes of hepatocytes.
Tissue Specificity Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:22232210}.
Top Pathways Bile secretion

OATP-C (A-3) - sc-271157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OATP-C (A-3): sc-271157. Western blot analysis of OATP-C expression in Caco-2 whole cell lysate.

OATP-C (H-60) - sc-33609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

OATP-C (N-16) - sc-18433 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OATP-C (N-16): sc-18433. Western blot analysis of OATP-C expression in SW480 whole cell lysate.

Anti-OATP2 antibody - ab103065 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-OATP2 antibody (ab103065) at 1/100 dilution + HepG2 cell lysate at 35 µg

Anti-OATP2 antibody [ESL] - ab15441 from Abcam

Prices $373.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone ESL

Anti-OATP2 antibody [MDQ] - ab15442 from Abcam

Prices $378.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone MDQ
Immunocytochemistry/Immunofluorescence analysis of HepG2 cells labeling OATP2 (green) with ab15542 at 1/20. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue). Cells were fixed with formaldehyde and incubated with the primary antibody overnight at 4°C. A DyLight 488-conjugated secondary antibody was used. 60X magnification. Right - negative control.

Anti-SLCO1B1 / OATP2 Antibody (C-Terminus) - LS-C8521 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (C-Terminus) - LS-C8522 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (aa267-293, AP) - LS-C240973 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (aa267-293, Biotin) - LS-C240974 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (aa267-293, APC) - LS-C240975 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (C-Terminus, clone mESL) - LS-C37834 from LifeSpan Bioscience

Prices $560.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone mESL

Anti-SLCO1B1 / OATP2 Antibody (aa267-293, FITC) - LS-C240976 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (aa267-293, PE) - LS-C240979 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (aa273-302) - LS-C325179 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (C-Terminus) - LS-C336294 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (aa267-293, Azide-free, HRP) - LS-C248196 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 / OATP2 Antibody (C-Terminus) - LS-C116247 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLCO1B1 / OATP2 antibody LS-C116247 Western blot of HepG2 cell lysate.

Anti-SLCO1B1 / OATP2 Antibody (aa267-293) - LS-C161285 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of SLCO1B1 Antibody in HepG2 cell line lysates (35 ug/lane). SLCO1B1 (arrow) was detected using the purified antibody.

OATP2/8 Antibody (MDQ) - NB100-74482 from Novus Biologicals

Prices $199.00, $329.00
Sizes 100 µl, 500 µl
Host Mouse
Clonality Monoclonal
Clone MDQ
Immunocytochemistry/Immunofluorescence: OATP2/8 Antibody (MDQ) [NB100-74482] - Analysis of OATP8 in HepG2 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a OATP8 monoclonal antibody at a dilution of 1:20 overnight at 4C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. OATP8 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown.

OATP1B1/OATP2 Antibody (ESL) - NB100-74481 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone ESL

OATP1B1/OATP2 Antibody - H00010599-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Anti-SLCO1B1 antibody produced in rabbit - SAB4300781 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-SLCO1B1 (CENTER) antibody produced in rabbit - SAB1304781 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLCO1B1 antibody produced in rabbit - SAB2105541 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLCO1B1: <B>Cat. No. SAB2105541</B>: SLCO1B1 in HepG2 cell lysates with SLCO1B1 antibody at 1.0 μg/mL.
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