| Gene Symbol |
SLCO1B1
|
| Entrez Gene |
10599
|
| Alt Symbol |
HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier organic anion transporter family, member 1B1
|
| Other Description |
OATP-2|liver-specific organic anion transporter 1|sodium-independent organic anion-transporting polypeptide 2|solute carrier family 21 (organic anion transporter), member 6|solute carrier family 21 member 6|solute carrier organic anion transporter family member 1B1
|
| Swissprots |
Q9NQ37 Q9Y6L6 Q9UH89 Q9UBF3 Q29R64 B2R7G2
|
| Accessions |
AAX20114 AFV58023 AFV58024 AFV58025 CAB97007 CAI38410 CAJ33680 CAX52185 EAW96420 EAW96421 Q9Y6L6 AB026257 BAA78639 AF060500 AAD38323 AF205071 AAF20212 AJ132573 CAB62577 AK312970 BAG35809 BC005243 BC020696 AAH20696 BC054878 AAH54878 BC070172 AAH70172 BC105596 AAI05597 BC114376 AAI14377 NM_006446 NP_006437
|
| Function |
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:22232210}.
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein {ECO:0000269|PubMed:12196548}. Note=Detected in basolateral membranes of hepatocytes.
|
| Tissue Specificity |
Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:22232210}.
|
| Top Pathways |
Bile secretion
|