SLCO1B1

Gene Symbol	SLCO1B1
Entrez Gene	10599
Alt Symbol	HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6
Species	Human
Gene Type	protein-coding
Description	solute carrier organic anion transporter family, member 1B1
Other Description	OATP-2|liver-specific organic anion transporter 1|sodium-independent organic anion-transporting polypeptide 2|solute carrier family 21 (organic anion transporter), member 6|solute carrier family 21 member 6|solute carrier organic anion transporter family member 1B1
Swissprots	Q9NQ37 Q9Y6L6 Q9UH89 Q9UBF3 Q29R64 B2R7G2
Accessions	AAX20114 AFV58023 AFV58024 AFV58025 CAB97007 CAI38410 CAJ33680 CAX52185 EAW96420 EAW96421 Q9Y6L6 AB026257 BAA78639 AF060500 AAD38323 AF205071 AAF20212 AJ132573 CAB62577 AK312970 BAG35809 BC005243 BC020696 AAH20696 BC054878 AAH54878 BC070172 AAH70172 BC105596 AAI05597 BC114376 AAI14377 NM_006446 NP_006437
Function	Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:22232210}.
Subcellular Location	Basolateral cell membrane {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein {ECO:0000269|PubMed:12196548}. Note=Detected in basolateral membranes of hepatocytes.
Tissue Specificity	Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:22232210}.
Top Pathways	Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OATP2 protein fragment - ab112394 from Abcam Category Protein Source Wheat germ Species Human

LST1 Antibody Blocking Peptide - LS-E5003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LST1 Antibody Blocking Peptide - LS-E23425 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLCO1B1 / OATP2 Antibody Blocking Peptide - LS-E16144 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLCO1B1 / OATP2 Antibody Blocking Peptide - LS-E10219 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human OATP1B1/OATP2 Protein - H00010599-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LST1 Protein - H00007940-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SLCO1B1-Antibody-Center-Blocking-Peptide - BP9609c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SLCO1B1 Blocking Peptide - 33R-4001 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SLCO1B1 / OATP2 - H00010599-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLCO1B1 / OATP2 - H00010599-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SLCO1B1 Peptide - 8197P from ProSci Category Peptide Species Human

SLCO1B1 fusion protein - ag16545 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SLCO1B1 fusion protein - Ag17407 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SLCO1B1 - SLCO1B1-27769TH from Creative Biomart Category Protein Source Wheat germ

LST1 Recombinant Protein Antigen - NBP2-48799PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

LST1 Peptide, Human - M34GP08974H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLCO1B1 Peptide, Human - M34GP14671H from Creative Peptides Category Peptide Source Synthetic. Species Human

Solute carrier organic anion transporter family member 1B1 (SLCO1B1), Recombinant Protein - MBS7102936 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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