CTNND1

Gene Symbol CTNND1
Entrez Gene 1500
Alt Symbol CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN)
Species Human
Gene Type protein-coding
Description catenin (cadherin-associated protein), delta 1
Other Description cadherin-associated Src substrate|catenin delta-1|p120 catenin
Swissprots Q9UP72 O60715 O60714 O60713 O60716 Q9UP73 Q6DHZ7 O15088 O60935 Q6RBX8 Q9UP71 A8K939
Accessions AAR84236 EAW73785 EAW73786 EAW73787 EAW73788 EAW73789 EAW73790 EAW73791 EAW73792 O60716 AF062317 AAC39802 AF062318 AAC39803 AF062319 AAC39804 AF062320 AAC39805 AF062321 AAC39806 AF062322 AAC39807 AF062323 AAC39808 AF062324 AAC39809 AF062325 AAC39810 AF062326 AAC39811 AF062327 AAC39812 AF062328 AAC39813 AF062329 AAC39814 AF062330 AAC39815 AF062331 AAC39816 AF062332 AAC39817 AF062333 AAC39818 AF062334 AAC39819 AF062335 AAC39820 AF062336 AAC39821 AF062337 AAC39822 AF062338 AAC39823 AF062339 AAC39824 AF062340 AAC39825 AF062341 AAC39826 AF062342 AAC39827 AF062343 AAC39828 AF062344 AAC39829 AI079200 AI088791 AK292554 BAF85243 AL698868 BC010501 AAH10501 BC075795 AAH75795 BP217375 BT007333 AAP35997 CN431494 CR749275 CAH18130 DB090596 NM_001085458 NP_001078927 NM_001085459 NP_001078928 NM_001085460 NP_001078929 NM_001085461 NP_001078930 NM_001085462 NP_001078931 NM_001085463 NP_001078932 NM_001085464 NP_001078933 NM_001085465 NP_001078934 NM_001085466 NP_001078935 NM_001085467 NP_001078936 NM_001085468 NP_001078937 NM_001085469 NP_001078938 NM_001206883 NP_001193812 NM_001206884 NP_001193813 NM_001206885 NP_001193814 NM_001206886 NP_001193815 NM_001206887 NP_001193816 NM_001206888 NP_001193817 NM_001206889 NP_001193818 NM_001206890 NP_001193819 NM_001206891 NP_001193820 NM_001331 NP_001322
Function Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
Subcellular Location Isoform 2A: Nucleus.
Tissue Specificity Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:14699141}.
Top Pathways Adherens junction, Leukocyte transendothelial migration, Rap1 signaling pathway

Phospho-Catenin δ-1 (Tyr904) Antibody - 2910 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from overnight serum starved A431 cells, untreated or EGF-treated for 15 minutes, using Phospho-Catenin δ-1 (Tyr904) Antibody (upper) and Catenin δ-1 Antibody #4989 as a loading control (lower).

Phospho-Catenin δ-1 (Tyr228) Antibody - 2911 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431 cells, serum-starved overnight and then either left untreated or treated with EGF for 15 minutes, using Phospho-Catenin δ-1 (Tyr228) Antibody (upper) and Catenin δ-1 Antibody #4989 as a loading control (lower).

Phospho-Catenin δ-1 (Ser252) Antibody - 8477 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A-431 cells, untreated or treated with λ phosphatase, using Phospho-Catenin δ-1 (Ser252) Antibody (upper) and Catenin δ-1 Antibody #4989 (lower).

Phospho-Catenin δ-1 (Ser320) Antibody - 8016 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A-431 cells, untreated (-) or treated with λ phosphatase (+), using Phospho-Catenin δ-1 (Ser320) Antibody (upper) and Catenin δ-1 Antibody #4989 (lower).

Catenin δ-1 Antibody - 4989 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MDA-MB-231 and NIH/3T3 cells using Catenin δ-1 Antibody.

p120 (A-8) - sc-390327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p120 (A-8): sc-390327. Western blot analysis of p120 expression in non-transfected: sc-110760 (A) and human p120 transfected: sc-112342 (B) 293 whole cell lysates.

p120 (G-7) - sc-373751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p120 (G-7): sc-373751. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing membrane and cytoplasmic staining of glandular cells.

p120 (H-90) - sc-13957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of p120 isoform expression in NIH/3T3 whole cell lysate (A), NIH/3T3 nuclear extract (B) and RAW 264.7 whole cell lysate (C). Antibodies tested include p120 (15D2): sc-23872 (A) and p120 (H-90): sc-13957 (B,C).

p120 (M-19) - sc-1730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p120 (M-19): sc-1730. Western blot analysis of p120 isoform expression in NIH/3T3 (A) and RAW 264.7 (B) whole cell lysates.

p120 (15D2) - sc-23872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p120 (15D2): sc-23872. Western blot analysis of p120 expression in human p120 transfected: sc-112342 (A) and non-transfected: sc-110760 (B) 293 whole cell lysates.

p120 (6H11) - sc-23873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p120 (6H11): sc-23873. Western blot analysis of p120 isoformexpression in HeLa (A), MDCK (B), Rat-2 (C) and SL-29 (D) whole cell lysates.

p-p120 (pS288.47) - sc-293002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-p120 (pS288.47): sc-293002. Immunofluorescence staining of methanol-fixed ECV304 cells treated with Pervanadate (Sodium Orthovanadate: sc-3540 + Hydrogen Peroxide: sc-20336) (A) untreated (B) and treated with Pervanadate and Lambda Phosphatase: sc-200312 (C).

p-p120 (pT910.27) - sc-293008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-p120 (pT910.27): sc-293008. Immunofluorescence staining of methanol-fixed ECV304 cells treated with Pervanadate (Sodium Orthovanadate: sc-3540 + Hydrogen Peroxide: sc-20336) (A) untreated (B) and treated with Pervanadate and Lambda Phosphatase: sc-200312 (C).

p-p120 (pS288.20A) - sc-293003 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-p120 (pS268.9A) - sc-293000 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-p120 (pS268.9A): sc-293000. Western blot analysis of p120 phosphorylation in Calyculin A treated A-431 whole cell lysates either untreated (A) or treated (B) with lambda phosphatase.

p-p120 (pS288.6A) - sc-293006 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of p120 phosphorylation in non-transfected: sc-110760 (A,D), untreated human p120 transfected: sc-112342 (B,E) and lambda protein phosphatase (sc-200312A) treated human p120 transfected: sc-112342 (C,F) 293 whole cell lysates. Antibodies tested include p-p120 (pS288.6A): sc-293006 (A,B,C) and p120 (M-19): sc-1730 (D,E,F).

p-p120 (pY228.15A) - sc-293012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of p120 phosphorylation in non-transfected: sc-110760 (A,D), untreated human p120 transfected: sc-112342 (B,E) and lambda protein phosphatase (sc-200312A) treated human p120 transfected: sc-112342 (C,F) 293 whole cell lysates. Antibodies tested include p-p120 (pY228.15A): sc-293012 (A,B,C) and p120 (M-19): sc-1730 (D,E,F).

p-p120 (pY228.19A) - sc-293011 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-p120 (pY228.19A): sc-293011. Immunofluorescence staining of methanol-fixed ECV304 cells treated with Pervanadate (Sodium Orthovanadate: sc-3540 + Hydrogen Peroxide: sc-20336) (A) untreated (B) and treated with Pervanadate and Lambda Phosphatase: sc-200312 (C).

p-p120 (pY228.22A) - sc-293013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of p120 phosphorylation in non-transfected: sc-110760 (A,D), untreated human p120 transfected: sc-112342 (B,E) and lambda protein phosphatase (sc-200312A) treated human p120 transfected: sc-112342 (C,F) 293 whole cell lysates. Antibodies tested include p-p120 (pY228.22A): sc-293013 (A,B,C) and p120 (M-19): sc-1730 (D,E,F).

p-p120 (pY291.15A) - sc-136475 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-p120 (pY291.15A): sc-136475. Western blot analysis of p120 phosphorylation in pervanadate-treated human endothelial cells either untreated (A) or treated (B) with alkaline phosphatase.

p-p120 (pY96.6A) - sc-293017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-p120 (pY228.21A) - sc-136015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-p120 (pY228.21A): sc-136015. Western blot analysis of p120 phosphorylation in untreated (A) and pervanadate-treated (B) human endothelial cells.

p-p120 (pY280.18) - sc-136016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
p-p120 (pY280.18): sc-136016. Western blot analysis of p120 phosphorylation in pervanadate-treated human endothelial cells either untreated (A) or treated (B) with alkaline phosphatase.

Anti-delta 1 Catenin (phospho S268) antibody [EPR2380] - ab79545 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2380
All lanes : Anti-delta 1 Catenin (phospho S268) antibody [EPR2380] (ab79545) at 1/5000 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate treated with Calyculin ALysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-delta 1 Catenin (phospho T310) antibody [EPR2382] - ab81318 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2382
All lanes : Anti-delta 1 Catenin (phospho T310) antibody [EPR2382] (ab81318) at 1/5000 dilutionLane 1 : 293T cell lysates untreated Lane 2 : 293T cell lysates treated with calyculin ALysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti rabbit at 1/2000 dilution
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