CTNND1

Gene Symbol	CTNND1
Entrez Gene	1500
Alt Symbol	CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN)
Species	Human
Gene Type	protein-coding
Description	catenin (cadherin-associated protein), delta 1
Other Description	cadherin-associated Src substrate|catenin delta-1|p120 catenin
Swissprots	Q9UP72 O60715 O60714 O60713 O60716 Q9UP73 Q6DHZ7 O15088 O60935 Q6RBX8 Q9UP71 A8K939
Accessions	AAR84236 EAW73785 EAW73786 EAW73787 EAW73788 EAW73789 EAW73790 EAW73791 EAW73792 O60716 AF062317 AAC39802 AF062318 AAC39803 AF062319 AAC39804 AF062320 AAC39805 AF062321 AAC39806 AF062322 AAC39807 AF062323 AAC39808 AF062324 AAC39809 AF062325 AAC39810 AF062326 AAC39811 AF062327 AAC39812 AF062328 AAC39813 AF062329 AAC39814 AF062330 AAC39815 AF062331 AAC39816 AF062332 AAC39817 AF062333 AAC39818 AF062334 AAC39819 AF062335 AAC39820 AF062336 AAC39821 AF062337 AAC39822 AF062338 AAC39823 AF062339 AAC39824 AF062340 AAC39825 AF062341 AAC39826 AF062342 AAC39827 AF062343 AAC39828 AF062344 AAC39829 AI079200 AI088791 AK292554 BAF85243 AL698868 BC010501 AAH10501 BC075795 AAH75795 BP217375 BT007333 AAP35997 CN431494 CR749275 CAH18130 DB090596 NM_001085458 NP_001078927 NM_001085459 NP_001078928 NM_001085460 NP_001078929 NM_001085461 NP_001078930 NM_001085462 NP_001078931 NM_001085463 NP_001078932 NM_001085464 NP_001078933 NM_001085465 NP_001078934 NM_001085466 NP_001078935 NM_001085467 NP_001078936 NM_001085468 NP_001078937 NM_001085469 NP_001078938 NM_001206883 NP_001193812 NM_001206884 NP_001193813 NM_001206885 NP_001193814 NM_001206886 NP_001193815 NM_001206887 NP_001193816 NM_001206888 NP_001193817 NM_001206889 NP_001193818 NM_001206890 NP_001193819 NM_001206891 NP_001193820 NM_001331 NP_001322
Function	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
Subcellular Location	Isoform 2A: Nucleus.
Tissue Specificity	Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:14699141}.
Top Pathways	Adherens junction, Leukocyte transendothelial migration, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

p120 CRISPR/Cas9 KO Plasmid (h) - sc-400943 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 HDR Plasmid (h) - sc-400943-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 Double Nickase Plasmid (h) - sc-400943-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 Double Nickase Plasmid (h2) - sc-400943-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 CRISPR Activation Plasmid (h) - sc-400943-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 CRISPR Activation Plasmid (h2) - sc-400943-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 Lentiviral Activation Particles (h) - sc-400943-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 Lentiviral Activation Particles (h2) - sc-400943-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p120 siRNA (h) - sc-36139 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p120 shRNA Plasmid (h) - sc-36139-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p120 shRNA (h) Lentiviral Particles - sc-36139-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU093581 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6739 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6739 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11897 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11897

CTNND1 siRNA (Human) - CRH1061 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CTNND1 - MBS8208535 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CTNND1(NM_001331.2) - SHG171919 from Creative biogene Category siRNA Species Reactivities Human

Human CTNND1 siRNA - orb261563 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CTNND1 shRNA Plasmid (Human) - CHH1061 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CTNND1 miRNA 3'UTR clone - MiUTR1H-02531 from Creative biogene Species Reactivities Human

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