CTNND1

Gene Symbol	CTNND1
Entrez Gene	1500
Alt Symbol	CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN)
Species	Human
Gene Type	protein-coding
Description	catenin (cadherin-associated protein), delta 1
Other Description	cadherin-associated Src substrate|catenin delta-1|p120 catenin
Swissprots	Q9UP72 O60715 O60714 O60713 O60716 Q9UP73 Q6DHZ7 O15088 O60935 Q6RBX8 Q9UP71 A8K939
Accessions	AAR84236 EAW73785 EAW73786 EAW73787 EAW73788 EAW73789 EAW73790 EAW73791 EAW73792 O60716 AF062317 AAC39802 AF062318 AAC39803 AF062319 AAC39804 AF062320 AAC39805 AF062321 AAC39806 AF062322 AAC39807 AF062323 AAC39808 AF062324 AAC39809 AF062325 AAC39810 AF062326 AAC39811 AF062327 AAC39812 AF062328 AAC39813 AF062329 AAC39814 AF062330 AAC39815 AF062331 AAC39816 AF062332 AAC39817 AF062333 AAC39818 AF062334 AAC39819 AF062335 AAC39820 AF062336 AAC39821 AF062337 AAC39822 AF062338 AAC39823 AF062339 AAC39824 AF062340 AAC39825 AF062341 AAC39826 AF062342 AAC39827 AF062343 AAC39828 AF062344 AAC39829 AI079200 AI088791 AK292554 BAF85243 AL698868 BC010501 AAH10501 BC075795 AAH75795 BP217375 BT007333 AAP35997 CN431494 CR749275 CAH18130 DB090596 NM_001085458 NP_001078927 NM_001085459 NP_001078928 NM_001085460 NP_001078929 NM_001085461 NP_001078930 NM_001085462 NP_001078931 NM_001085463 NP_001078932 NM_001085464 NP_001078933 NM_001085465 NP_001078934 NM_001085466 NP_001078935 NM_001085467 NP_001078936 NM_001085468 NP_001078937 NM_001085469 NP_001078938 NM_001206883 NP_001193812 NM_001206884 NP_001193813 NM_001206885 NP_001193814 NM_001206886 NP_001193815 NM_001206887 NP_001193816 NM_001206888 NP_001193817 NM_001206889 NP_001193818 NM_001206890 NP_001193819 NM_001206891 NP_001193820 NM_001331 NP_001322
Function	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
Subcellular Location	Isoform 2A: Nucleus.
Tissue Specificity	Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:14699141}.
Top Pathways	Adherens junction, Leukocyte transendothelial migration, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human delta 1 Catenin peptide - ab72863 from Abcam Category Peptide

Human delta 1 Catenin protein fragment - ab114472 from Abcam Category Protein Source Wheat germ Species Human

CTNND1 / p120 Catenin Antibody Blocking Peptide - LS-E18616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTNND1 / p120 Catenin Antibody Blocking Peptide - LS-E18617 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human p120-catenin Protein - H00001500-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CTND1-Antibody-Center-Blocking-peptide - BP11572c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Catenin delta-1 - H00001500-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Catenin delta-1 - H00001500-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CTNND1 fusion protein - ag2824 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CTNND1 - CTNND1-26995TH from Creative Biomart Category Protein Source Wheat germ

Catenin-δ1 (G224) Peptide - BS2992P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Catenin delta-1(CTNND1) ,partial - CSB-YP006172HU CSB-EP006172HU CSB-BP006172HU CSB-MP006172HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Catenin delta 1 (pY228) Blocking Peptide - abx161830 from Abbexa Category Peptide Species Human, Mouse, Monkey

Catenin delta-1 (transcript variant 1) - TP322771 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Catenin delta-1 (CTNND1), partial, Recombinant Protein - MBS1194645 from MyBioSource Category Protein Prices $950.00, $950.00, $1,170.00, $1,170.00, $1,390.00, $1,390.00, $1,850.00, $1,850.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

p120-catenin Recombinant Protein Antigen - NBP2-38130PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

p120-catenin Recombinant Protein Antigen - NBP1-85383PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HUMAN-CTNND1_isform-2ABCY174-Blocking-Peptide - BP20722b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Human

CTNND1 Peptide, Human - M34GP03805H from Creative Peptides Category Peptide Source Synthetic. Species Human

Catenin delta 1 (pY228) Blocking Peptide - CBP4619 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Monkey

Catenin delta 1 Blocking Peptide - CBP7466 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

CTNND1 (Phospho-Y228) Blocking Peptide - orb392964 from Biorbyt Category Peptide Prices $340.00, $587.00 Sizes 1 mg, 5 mg Species Human, Mouse, Monkey

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