| Gene Symbol | C3AR1 |
|---|---|
| Entrez Gene | 719 |
| Alt Symbol | AZ3B, C3AR, HNFAG09 |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 3a receptor 1 |
| Other Description | C3a anaphylatoxin chemotactic receptor|C3a-R|complement component 3 receptor 1 |
| Swissprots | Q16581 O43771 Q92868 |
| Accessions | AAP23198 AAR13862 BAC06088 EAW88640 EAW88641 Q16581 AK223388 BAD97108 AK290242 BAF82931 AK312458 BAG35365 BC020742 AAH20742 DQ892004 ABM82930 DQ895197 ABM86123 DQ896840 ABM87839 U28488 AAC50374 U62027 AAC50657 Z73157 CAA97504 NM_004054 NP_004045 |
| Function | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. |
| Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction |