Gene Symbol | C3AR1 |
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Entrez Gene | 719 |
Alt Symbol | AZ3B, C3AR, HNFAG09 |
Species | Human |
Gene Type | protein-coding |
Description | complement component 3a receptor 1 |
Other Description | C3a anaphylatoxin chemotactic receptor|C3a-R|complement component 3 receptor 1 |
Swissprots | Q16581 O43771 Q92868 |
Accessions | AAP23198 AAR13862 BAC06088 EAW88640 EAW88641 Q16581 AK223388 BAD97108 AK290242 BAF82931 AK312458 BAG35365 BC020742 AAH20742 DQ892004 ABM82930 DQ895197 ABM86123 DQ896840 ABM87839 U28488 AAC50374 U62027 AAC50657 Z73157 CAA97504 NM_004054 NP_004045 |
Function | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. |
Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction |
C3aR CRISPR/Cas9 KO Plasmid (h) - sc-401448 from Santa Cruz Biotechnology
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C3aR HDR Plasmid (h) - sc-401448-HDR from Santa Cruz Biotechnology
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C3aR Double Nickase Plasmid (h) - sc-401448-NIC from Santa Cruz Biotechnology
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C3aR Double Nickase Plasmid (h2) - sc-401448-NIC-2 from Santa Cruz Biotechnology
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C3aR CRISPR Activation Plasmid (h) - sc-401448-ACT from Santa Cruz Biotechnology
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C3aR CRISPR Activation Plasmid (h2) - sc-401448-ACT-2 from Santa Cruz Biotechnology
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C3aR Lentiviral Activation Particles (h) - sc-401448-LAC from Santa Cruz Biotechnology
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C3aR Lentiviral Activation Particles (h2) - sc-401448-LAC-2 from Santa Cruz Biotechnology
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C3aR siRNA (h) - sc-42840 from Santa Cruz Biotechnology
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C3aR shRNA Plasmid (h) - sc-42840-SH from Santa Cruz Biotechnology
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C3aR shRNA (h) Lentiviral Particles - sc-42840-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU030821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4872 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4872 from Sigma-Aldrich
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C3AR1 siRNA (Human) - CRH0498 from Cohesion Biosciences
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Complement Component C3a R RNAi - H00000719-R02 from Novus Biologicals
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C3AR1 - MBS8210435 from MyBioSource
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shRNA set against Human C3AR1 (NM_004054.2) - SHH251573 from Creative biogene
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shRNA set against Human C3AR1(NM_004054.2) - SHG124395 from Creative biogene
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Human C3AR1 siRNA - orb261000 from Biorbyt
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C3AR1 shRNA Plasmid (Human) - CHH0498 from Cohesion Biosciences
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C3AR1 miRNA 3'UTR clone - MiUTR3H-07509 from Creative biogene
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