| Gene Symbol |
SMC4
|
| Entrez Gene |
10051
|
| Alt Symbol |
CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
structural maintenance of chromosomes 4
|
| Other Description |
SMC protein 4|SMC4 structural maintenance of chromosomes 4-like 1|XCAP-C homolog|chromosome-associated polypeptide C|structural maintenance of chromosomes protein 4
|
| Swissprots |
Q8NDL4 O95752 A6NLT9 Q9NTJ3 Q9UNT9 D3DNL8
|
| Accessions |
EAW78639 EAW78640 EAW78641 EAW78642 Q9NTJ3 AB019987 BAA73535 AF092564 AAC72361 AK002200 AK026361 AK122939 BAG53807 AK128143 BAG54637 AK225437 AK307508 AK315070 AL136877 CAB66811 AL833949 CAD38803 BC001557 AAH01557 BC065259 AAH65259 BC070161 AAH70161 BC106033 AAI06034 BC146370 AAI46371 BC148796 AAI48797 BI090399 BQ575962 DB444342 XM_006713459 XP_006713522 XM_011512311 XP_011510613 XM_011512312 XP_011510614 XM_011512313 XP_011510615 NM_001002799 NM_001002800 NP_001002800 NM_001288753 NP_001275682 NM_005496 NP_005487
|
| Function |
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
|
| Tissue Specificity |
Widely expressed. Higher expression in testis, colon, thymus. {ECO:0000269|PubMed:10319587}.
|
