SMC4

Gene Symbol SMC4
Entrez Gene 10051
Alt Symbol CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 4
Other Description SMC protein 4|SMC4 structural maintenance of chromosomes 4-like 1|XCAP-C homolog|chromosome-associated polypeptide C|structural maintenance of chromosomes protein 4
Swissprots Q8NDL4 O95752 A6NLT9 Q9NTJ3 Q9UNT9 D3DNL8
Accessions EAW78639 EAW78640 EAW78641 EAW78642 Q9NTJ3 AB019987 BAA73535 AF092564 AAC72361 AK002200 AK026361 AK122939 BAG53807 AK128143 BAG54637 AK225437 AK307508 AK315070 AL136877 CAB66811 AL833949 CAD38803 BC001557 AAH01557 BC065259 AAH65259 BC070161 AAH70161 BC106033 AAI06034 BC146370 AAI46371 BC148796 AAI48797 BI090399 BQ575962 DB444342 XM_006713459 XP_006713522 XM_011512311 XP_011510613 XM_011512312 XP_011510614 XM_011512313 XP_011510615 NM_001002799 NM_001002800 NP_001002800 NM_001288753 NP_001275682 NM_005496 NP_005487
Function Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Tissue Specificity Widely expressed. Higher expression in testis, colon, thymus. {ECO:0000269|PubMed:10319587}.

SMC4 CRISPR/Cas9 KO Plasmid (h) - sc-405067 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 HDR Plasmid (h) - sc-405067-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 Double Nickase Plasmid (h) - sc-405067-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 Double Nickase Plasmid (h2) - sc-405067-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 CRISPR Activation Plasmid (h) - sc-405067-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 CRISPR Activation Plasmid (h2) - sc-405067-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 Lentiviral Activation Particles (h) - sc-405067-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 Lentiviral Activation Particles (h2) - sc-405067-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC4 siRNA (h) - sc-38384 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC4 shRNA Plasmid (h) - sc-38384-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC4 shRNA (h) Lentiviral Particles - sc-38384-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC4 RNAi - H00010051-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMC4 RNAi - H00010051-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMC4 RNAi - H00010051-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU068411 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19777 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19777 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08297 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08297

SMC4 siRNA (Human) - CRH6767 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMC4 - MBS8219580 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Smc4 (NM_005496.3) - SHH413276 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SMC4(NM_001002800.1) - SHL018486 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMC4 siRNA - orb267269 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMC4 shRNA Plasmid (Human) - CHH6767 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMC4 miRNA 3'UTR clone - MiUTR1H-09655 from Creative biogene

Species Reactivities Human
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