MVP

Gene Symbol MVP
Entrez Gene 9961
Alt Symbol LRP, VAULT1
Species Human
Gene Type protein-coding
Description major vault protein
Other Description lung resistance-related protein
Swissprots Q14764 Q9BQT1 Q9UBD1 Q96BG4 Q9BPW6
Accessions CAB55354 CAB55355 CAC35313 EAW79979 EAW79980 EAW79981 EAW79982 EAW79983 EAW79984 EAW79985 EAW79986 EAW79987 Q14764 AJ291366 CAC35314 AJ291367 CAC35316 AK293302 BAG56823 AK298238 BAG60505 AK301130 BAG62723 AK302052 BAG63442 AK310168 BC008932 BC015623 AAH15623 BM999583 BQ932800 BU151678 DA842337 DA940597 DQ896352 ABM87351 EU176426 ABW03877 KJ534884 AHW56524 KJ534885 AHW56525 KJ534886 AHW56526 KJ534966 AHW56606 KJ534975 AHW56615 KJ534976 AHW56616 KJ534990 AHW56630 KJ535063 AHW56702 X79882 CAA56256 NM_001293204 NP_001280133 NM_001293205 NP_001280134 NM_005115 NP_005106 NM_017458 NP_059447
Function Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.
Subcellular Location Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
Tissue Specificity Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

LRP (E-2) - sc-390134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP (E-2): sc-390134. Western blot analysis of LRP expression in non-transfected 293T: sc-117752 (A), human LRP transfected 293T: sc-170301 (B), HeLa (C) and U-87 MG (D) whole cell lysates.

LRP (F-7) - sc-390141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP (F-7): sc-390141. Western blot analysis of LRP expression in HeLa (A) and U-87 MG (B) whole cell lysates.

LRP (H-300) - sc-366042 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRP (H-300): sc-366042. Western blot analysis of LRP expression in HeLa (A) and U-87 MG (B) whole cell lysates.

LRP (1014) - sc-23916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP (1014): sc-23916. Western blot analysis of LRP expression in U-87 MG (A) and T98G (B) whole cell lysates.

LRP (1032) - sc-23917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP (1032): sc-23917. Immunofluorescence staining of methanol-fixed MCF7 cells showing cytoplasmic localization.

LRP (G-14) - sc-18701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP (G-14): sc-18701. Western blot analysis of LRP expression in U-87 MG (A), T98G (B) and Caki-1 (C) whole cell lysates.

LRP (C-14) - sc-18703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP (C-14): sc-18703. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic and nuclear staining of respiratory epithelial cells.

LRP (N-17) - sc-18700 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP (N-17): sc-18700. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic staining of respiratory epithelial cells.

LRP (42) - sc-135975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
LRP (42): sc-135975. Western blot analysis of LRP expression in human endothelial whole cell lysate.

Anti-MVP antibody - ab202971 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling MVP with ab202971 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-MVP antibody - ab38309 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MVP antibody (ab38309) at 1/100 dilution + A375 lysate

Anti-MVP antibody - ab115928 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115928, at 10 µg/ml, staining MVP in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MVP antibody [0.N.389] - ab14562 from Abcam

Prices $378.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 0.N.389

Anti-MVP antibody [0.N.389] - ab14563 from Abcam

Prices $372.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 0.N.389

Anti-MVP antibody [1032] - ab2376 from Abcam

Prices $379.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 1032
ab2376 - immunohistochemistry Formalin fixed paraffin embedded human breast carcinoma stained with MVP, using ABC and DAB chromogen.

Anti-MVP antibody [1032] (Biotin) - ab79213 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 1032

Anti-MVP antibody [EPR13226(B)] - ab177145 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13226(B)
All lanes : Anti-MVP antibody [EPR13226(B)] (ab177145) at 1/1000 dilutionLane 1 : Human spleen lysateLane 2 : Calu3 lysateLane 3 : A549 lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MVP antibody [EPR13227(B)] - ab175239 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13227(B)
All lanes : Anti-MVP antibody [EPR13227(B)] (ab175239) at 1/10000 dilutionLane 1 : A549 cell lysateLane 2 : Calu-3 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-MVP antibody [LMR5] - ab3374 from Abcam

Prices $372.00
Sizes 250 µl
Host Rat
Clonality Monoclonal
Clone LMR5

Anti-MVP antibody [LRP-56] - ab3367 from Abcam

Prices $372.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone LRP-56

Anti-MVP antibody [SPM280], prediluted - ab54301 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM280
ab54301 staining human MVP in human breast carcinoma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-MVP / VAULT1 Antibody - LS-C8526 from LifeSpan Bioscience

Prices $445.00
Sizes 125 µg
Host Mouse
Clonality Monoclonal

Anti-MVP / VAULT1 Antibody - LS-C8527 from LifeSpan Bioscience

Prices $445.00
Sizes 25 µg
Host Rat
Clonality Monoclonal

Anti-MVP / VAULT1 Antibody - LS-C8533 from LifeSpan Bioscience

Prices $845.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-MVP / VAULT1 Antibody - LS-C8531 from LifeSpan Bioscience

Prices $475.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
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