| Gene Symbol | MVP |
|---|---|
| Entrez Gene | 9961 |
| Alt Symbol | LRP, VAULT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | major vault protein |
| Other Description | lung resistance-related protein |
| Swissprots | Q14764 Q9BQT1 Q9UBD1 Q96BG4 Q9BPW6 |
| Accessions | CAB55354 CAB55355 CAC35313 EAW79979 EAW79980 EAW79981 EAW79982 EAW79983 EAW79984 EAW79985 EAW79986 EAW79987 Q14764 AJ291366 CAC35314 AJ291367 CAC35316 AK293302 BAG56823 AK298238 BAG60505 AK301130 BAG62723 AK302052 BAG63442 AK310168 BC008932 BC015623 AAH15623 BM999583 BQ932800 BU151678 DA842337 DA940597 DQ896352 ABM87351 EU176426 ABW03877 KJ534884 AHW56524 KJ534885 AHW56525 KJ534886 AHW56526 KJ534966 AHW56606 KJ534975 AHW56615 KJ534976 AHW56616 KJ534990 AHW56630 KJ535063 AHW56702 X79882 CAA56256 NM_001293204 NP_001280133 NM_001293205 NP_001280134 NM_005115 NP_005106 NM_017458 NP_059447 |
| Function | Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}. |
| Subcellular Location | Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment. |
| Tissue Specificity | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |