MVP

Gene Symbol	MVP
Entrez Gene	9961
Alt Symbol	LRP, VAULT1
Species	Human
Gene Type	protein-coding
Description	major vault protein
Other Description	lung resistance-related protein
Swissprots	Q14764 Q9BQT1 Q9UBD1 Q96BG4 Q9BPW6
Accessions	CAB55354 CAB55355 CAC35313 EAW79979 EAW79980 EAW79981 EAW79982 EAW79983 EAW79984 EAW79985 EAW79986 EAW79987 Q14764 AJ291366 CAC35314 AJ291367 CAC35316 AK293302 BAG56823 AK298238 BAG60505 AK301130 BAG62723 AK302052 BAG63442 AK310168 BC008932 BC015623 AAH15623 BM999583 BQ932800 BU151678 DA842337 DA940597 DQ896352 ABM87351 EU176426 ABW03877 KJ534884 AHW56524 KJ534885 AHW56525 KJ534886 AHW56526 KJ534966 AHW56606 KJ534975 AHW56615 KJ534976 AHW56616 KJ534990 AHW56630 KJ535063 AHW56702 X79882 CAA56256 NM_001293204 NP_001280133 NM_001293205 NP_001280134 NM_005115 NP_005106 NM_017458 NP_059447
Function	Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.
Subcellular Location	Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
Tissue Specificity	Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MVP full length protein - ab153030 from Abcam Category Protein Source Wheat germ Species Human

MVP-Antibody-C-term-Blocking-Peptide - BP6216a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MVP protein - orb244392 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Major Vault Protein - H00009961-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Major Vault Protein - H00009961-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MVP fusion protein - ag9366 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MVP fusion protein - Ag9593 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human MVP, GST-tagged - MVP-1117H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human MVP, GST-tagged - MVP-1115H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human MVP, MYC/DDK-tagged - MVP-1116H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Major Vault Protein (MVP) - RPB764Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Major vault protein(MVP) ,partial - CSB-YP015248HU CSB-BP015248HU CSB-MP015248HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Major vault protein - CSB-EP015248HU from Cusabio Category Protein Source E.coli Species Human

Major Vault Protein (transcript variant 2) - TP304841 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Major Vault Protein (transcript variant 1) - TP313533 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MVP Recombinant Protein (OPCA01742) - OPCA01742 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

MVP Recombinant Protein (OPCD05474) - OPCD05474 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant human Major vault protein - AP70571 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Major vault, Recombinant Protein - MBS9420480 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Major vault protein, Recombinant Protein - MBS1403097 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human MVP Protein (2-893 aa), His-SUMO-tagged - MVP-673H from Creative Biomart Category Protein Source E. coli Species Human

Search more