| Gene Symbol |
SH3GLB1
|
| Entrez Gene |
51100
|
| Alt Symbol |
Bif-1, CGI-61, PPP1R70, dJ612B15.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH3-domain GRB2-like endophilin B1
|
| Other Description |
Bax-interacting factor 1|SH3 domain-containing GRB2-like protein B1|SH3-containing protein SH3GLB1|endophilin-B1|protein phosphatase 1, regulatory subunit 70
|
| Swissprots |
Q9H3Z0 Q5H8U5 Q9NR47 Q9Y371 Q9NYA9 B4E182
|
| Accessions |
EAW73181 EAW73182 Q9Y371 AB007960 BAD88797 AF151819 AAD34056 AF257318 AAF81225 AF263293 AAF73017 AF350371 AAK27365 AI936794 AK001954 BAA91999 AK225864 AK303710 BAG64694 BC007455 AAH07455 DB038227 DB451777 DQ893029 ABM83955 DQ896273 ABM87272 XM_006710672 XP_006710735 XM_006710673 XP_006710736 XM_011541538 XP_011539840 NM_001206651 NP_001193580 NM_001206652 NP_001193581 NM_001206653 NP_001193582 NM_016009 NP_057093
|
| Function |
May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. {ECO:0000269|PubMed:11161816, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15452144}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:15452144}; Peripheral membrane protein {ECO:0000269|PubMed:15452144}. Note=Association with the Golgi apparatus depends on the cell type. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11161816, ECO:0000269|PubMed:11259440}.
|
| Top Pathways |
Endocytosis
|
![Western Blot: Bi-f-1/Endophilin-B1 Overexpression Lysate (Adult Normal) [NBL1-15933] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Bi-f-1/Endophilin-B1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1823_Bi-f-1-Endophilin-B1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15933-img0002.jpg)