PPARGC1A

Gene Symbol	PPARGC1A
Entrez Gene	10891
Alt Symbol	LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
Species	Human
Gene Type	protein-coding
Description	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Other Description	L-PGC-1alpha|PGC-1-alpha|PPAR gamma coactivator variant form|PPARGC-1-alpha|ligand effect modulator-6|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT|peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Swissprots	Q4W5M7 I3RTT7 I3RTT8 B7Z406 Q3LIG1 I3RTT5 Q9UN32 Q9UBK2 I3RTT9 I3RTT6 G8DM16
Accessions	AAF19083 AAY41058 ABX44665 EAW92811 EAW92812 Q9UBK2 AB061325 BAE46508 AF106698 AAF18573 AF159714 AAD51615 AF186379 AAD56250 AK024990 AK296591 BAH12392 AK301883 BAH13576 AK309261 BC029800 BC156323 AAI56324 BC157068 AAI57069 HQ695733 ADW77180 JQ772116 AFK29753 JQ772117 AFK29754 JQ772118 AFK29755 JQ772119 AFK29756 JQ772120 AFK29757 XM_005248130 XP_005248187 XM_005248131 XP_005248188 XM_005248132 XP_005248189 XM_005248134 XP_005248191 XM_011513764 XP_011512066 XM_011513765 XP_011512067 XM_011513766 XP_011512068 XM_011513767 XP_011512069 XM_011513768 XP_011512070 XM_011513769 XP_011512071 XM_011513770 XP_011512072 XM_011513771 XP_011512073 NM_013261 NP_037393
Function	Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. {ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23836911}.
Subcellular Location	Isoform 9: Nucleus {ECO:0000269|PubMed:22009745}.
Tissue Specificity	Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. {ECO:0000269|PubMed:10585775, ECO:0000269|PubMed:10643692, ECO:0000269|PubMed:10713165}.
Top Pathways	Insulin signaling pathway, Adipocytokine signaling pathway, Huntington's disease, AMPK signaling pathway, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPARGC1 ELISA Kit - abx054958 from Abbexa Category ELISA Kit

Peroxisome proliferative activated receptor gama coactivator 1 alpha, PPARGC1, Human, ELISA Kit - CSB-E11761h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a), Human, ELISA Kit - SEH337Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC1A, Human, ELISA Kit - E1160h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, ELISA Kit - MBS707053 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse PPARGC1A is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.5 pg/ml -1500 pg/ml.

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha - MBS9310974 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) - SEH337Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) - SEH337Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) - SEH337Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.125ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

human peroxisome proliferative activated receptor gama coactivator 1 alpha,PPARGC1 ELISA Kit - CSB-E11761h from Cusabio Category ELISA Kit Sensitivity 31.25pg/ml Range 125 pg/ml-8000 pg/ml

ELISA Kit for Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) - SEH337Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ELISA Kit - MBS288484 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15 ng/ml -10.0 ng/ml.

Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ELISA Kit - abx250593 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a), Human, ELISA Kit - DL-PPARgC1a-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ELISA Kit - MBS288117 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15 ng/mL -10.0 ng/mL.

PPARgammaC1alpha (Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha), CLIA Kit - MBS2531633 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Human PPARgC1a ELISA Kit - abx570663 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ELISA Kit - EKE53178 from Biomatik Category ELISA Kit Prices $685.00, $2,913.00, $5,483.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.19 ng/mL Range 0.312-20 ng/mL

PPARGC1A - EKH2652 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

PPARGC1A ELISA Kit (Human) : 96 Wells (OKEH00824) - OKEH00824 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.19 ng/mL Range 0.312 - 20 ng/mL

Human PPARGC1A ELISA Kit - E028756 from Biobool Category ELISA Kit

Human Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ELISA Kit - EK2857 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.19ng/mL Range 0.312-20 ng/mL

Human Peroxisome proliferative activated receptor gama coactivator 1 alpha (PPARGC1) ELISA Kit - AE26473HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.057 ng/mL Range 0.156-10 ng/mL

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha, ELISA Kit - MBS763157 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a), ELISA Kit - MBS453938 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.061ng/mL Range 0.156-10ng/mL

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