PPARGC1A

Gene Symbol PPARGC1A
Entrez Gene 10891
Alt Symbol LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
Species Human
Gene Type protein-coding
Description peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Other Description L-PGC-1alpha|PGC-1-alpha|PPAR gamma coactivator variant form|PPARGC-1-alpha|ligand effect modulator-6|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT|peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Swissprots Q4W5M7 I3RTT7 I3RTT8 B7Z406 Q3LIG1 I3RTT5 Q9UN32 Q9UBK2 I3RTT9 I3RTT6 G8DM16
Accessions AAF19083 AAY41058 ABX44665 EAW92811 EAW92812 Q9UBK2 AB061325 BAE46508 AF106698 AAF18573 AF159714 AAD51615 AF186379 AAD56250 AK024990 AK296591 BAH12392 AK301883 BAH13576 AK309261 BC029800 BC156323 AAI56324 BC157068 AAI57069 HQ695733 ADW77180 JQ772116 AFK29753 JQ772117 AFK29754 JQ772118 AFK29755 JQ772119 AFK29756 JQ772120 AFK29757 XM_005248130 XP_005248187 XM_005248131 XP_005248188 XM_005248132 XP_005248189 XM_005248134 XP_005248191 XM_011513764 XP_011512066 XM_011513765 XP_011512067 XM_011513766 XP_011512068 XM_011513767 XP_011512069 XM_011513768 XP_011512070 XM_011513769 XP_011512071 XM_011513770 XP_011512072 XM_011513771 XP_011512073 NM_013261 NP_037393
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. {ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23836911}.
Subcellular Location Isoform 9: Nucleus {ECO:0000269|PubMed:22009745}.
Tissue Specificity Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. {ECO:0000269|PubMed:10585775, ECO:0000269|PubMed:10643692, ECO:0000269|PubMed:10713165}.
Top Pathways Insulin signaling pathway, Adipocytokine signaling pathway, Huntington's disease, AMPK signaling pathway, Glucagon signaling pathway

PGC-1α (3G6) Rabbit mAb - 2178 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 3G6
Western blot analysis of extracts from 293T cells, either mock transfected (-) or transfected with a construct expressing full-length Myc-DDK-tagged human wild-type PGC-1α (+), using PGC-1α (3G6) Rabbit mAb.

PGC1α Antibody - 4259 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse primary hepatocytes transfected with mouse wild-type (WT) PGC1α using PGC1α Antibody.

PGC-1 (H-300) - sc-13067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PGC-1 (H-300): sc-13067. Western blot analysis of PGC-1 expression in rat kidney tissue extract.

PGC-1 (K-15) - sc-5816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PGC-1 (K-15): sc-5816. Western blot analysis of PGC-1 expression in DU 145 (A) and K-562 (B) nuclear extracts.

PGC-1 (P-19) - sc-5815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PGC-1 (P-19): sc-5815. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing nuclear staining of cells in glomeruli and nuclear and cytoplasmic staining of cells in tubules.

Anti-PGC1 alpha + beta antibody - ab72230 from Abcam

Prices $391.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of 4% paraformaldehyde fixed HeLa cells (Human epithelial cells from cervix adenocarcinoma) labeling PGC1 alpha+beta with ab72230 at a 1/100 dilution showing nuclear staining. Permeabilisation using 0.1% tritonX-100.Secondary ab: Anti-Rabbit Alexa Fluor® 488 (ab150077) at 1/500 dilution. Counter stain is labeling tubulin (red) with ab7291 at 1/1000 dilution with secondary antibody Anti-Mouse AlexaFluor® 594 (ab150120) at 1/500 dilution. DAPI stains the nucleus in blue. -ve control 1 is ab72230 at 1/100 dilution, Anti-Mouse AlexaFluor® 594 (ab150120) at 1/500 dilution. -ve control 2 is ab7291 at 1/1000 dilution, Anti-Rabbit Alexa Fluor® 488 (ab150077) at 1/500 dilution.

Anti-PGC1 alpha antibody - ab77210 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-PGC1 alpha antibody (ab77210) at 1 µg/ml + Recombinant fragment of human PGC1 alpha at 0.1 µgSecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-PGC1 alpha antibody - ab84139 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84139, at a 1/250 dilution, staining PGC1 alpha in formalin fixed, paraffin embedded human stomach adenocarcinoma by Immunohistochemistry. Detection: DAB

Anti-PGC1 alpha antibody [PPARAH6] - ab51365 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone PPARAH6
Anti-PGC1 alpha antibody [PPARAH6] (ab51365) + Recombinant protein fragment (immunogen)

Anti-PGC1 alpha antibody - N-terminal - ab191838 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PGC1 alpha antibody - N-terminal (ab191838) at 1 µgLane 1 : Human heart tissue lysateLane 2 : Human heart tissue lysate with blocking peptide.Lysates/proteins at 15 µg per lane.

PGC1 alpha Antibody - NBP1-04676 from Novus Biologicals

Prices $129.00, $349.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PGC1 alpha Antibody [NBP1-04676] - Total protein from human adipose and skeletal muscle tissue, HeLa and A431 cells lines was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-PGC1-alpha in 1% non-fat milk in TBST and detected with an anti-rabbit HRP secondary antibody using chemiluminescence

PGC1 alpha Antibody - NB100-60955 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: PGC1 alpha Antibody [NB100-60955] - (0.1ug/ml) staining of Human Skeletal Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PGC1 alpha [p ser571] Antibody [Unconjugated] - AF6650 from Novus Biologicals

Prices $99.00, $289.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and Jurkat human acute T cell leukemia cell line untreated (-) or treated (+) with 10 nm Recombinant Human IGF‑I (Catalog # 291-G1) for 1 hour. PVDF Membrane was probed with 1 µg/mL of Rabbit Anti-Human Phospho-PGC1 alpha (S571) Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6650) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for Phospho-PGC1 alpha (S571) at approximately 120 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PGC1 alpha Antibody (2F9) - H00010891-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F9
Western Blot: PGC1 alpha Antibody (2F9) [H00010891-M04] - Analysis of PPARGC1A expression in U-2 OS (Cat # L022V1).

PGC1 alpha Antibody (1G8) - NBP2-37562 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8
Western Blot: PGC1 alpha Antibody (1G8) [NBP2-37562] - Western blot analysis using PGC-1alpha mAb against HEK293 (1) and PGC-1alpha-hIgGFc transfected HEK293 (2) cell lysate.

PGC1 alpha Antibody (3B5) - H00010891-M02 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B5
Immunocytochemistry/Immunofluorescence: PGC-1 alpha Antibody (3B5) [H00010891-M02] - HeLa cell.

PGC1 alpha Antibody - NB100-1750 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PGC1 alpha Antibody - H00010891-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

PGC1 alpha Antibody (2G8) - H00010891-M17 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G8
Western Blot: PGC1 alpha Antibody (2G8) [H00010891-M17] - PPARGC1A monoclonal antibody (M17), clone 2G8. Western Blot analysis of PPARGC1A expression in HL-60 ( Cat # L014V1 ).

PGC1 alpha Antibody (3G11) - H00010891-M12 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G11
Western Blot: PGC1 alpha Antibody (3G11) [H00010891-M12] - Analysis of PPARGC1A expression in human spleen.

PGC1 alpha Antibody (4A8) - H00010891-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A8
Western Blot: PGC1 alpha Antibody (4A8) [H00010891-M01] - PPARGC1A monoclonal antibody (M01), clone 4A8. Analysis of PPARGC1A expression in U-2 OS.

PGC1 alpha Antibody (2E11) - H00010891-M11 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E11
Western Blot: PGC1 alpha Antibody (2E11) [H00010891-M11] - PPARGC1A monoclonal antibody (M11), clone 2E11. Western Blot analysis of PPARGC1A expression in HL-60 ( Cat # L014V1 ).

PGC1 alpha Antibody (1E11) - H00010891-M05 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E11
ELISA: PGC-1 alpha Antibody (1E11) [H00010891-M05] - Detection limit for recombinant GST tagged PPARGC1A is approximately 0.3ng/ml as a capture antibody.

PGC1 alpha Antibody (2F10) - H00010891-M18 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F10
Western Blot: PGC1 alpha Antibody (2F10) [H00010891-M18] - PPARGC1A monoclonal antibody (M18), clone 2F10. Western Blot analysis of PPARGC1A expression in HL-60 ( Cat # L014V1 ).

PGC1 alpha Antibody (1F3) - H00010891-M03 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F3
ELISA: PGC-1 alpha Antibody (1F3) [H00010891-M03] - Detection limit for recombinant GST tagged PPARGC1A is approximately 0.3ng/ml as a capture antibody.
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