| Gene Symbol |
PPARGC1A
|
| Entrez Gene |
10891
|
| Alt Symbol |
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
|
| Other Description |
L-PGC-1alpha|PGC-1-alpha|PPAR gamma coactivator variant form|PPARGC-1-alpha|ligand effect modulator-6|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5|peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT|peroxisome proliferator-activated receptor gamma coactivator 1-alpha
|
| Swissprots |
Q4W5M7 I3RTT7 I3RTT8 B7Z406 Q3LIG1 I3RTT5 Q9UN32 Q9UBK2 I3RTT9 I3RTT6 G8DM16
|
| Accessions |
AAF19083 AAY41058 ABX44665 EAW92811 EAW92812 Q9UBK2 AB061325 BAE46508 AF106698 AAF18573 AF159714 AAD51615 AF186379 AAD56250 AK024990 AK296591 BAH12392 AK301883 BAH13576 AK309261 BC029800 BC156323 AAI56324 BC157068 AAI57069 HQ695733 ADW77180 JQ772116 AFK29753 JQ772117 AFK29754 JQ772118 AFK29755 JQ772119 AFK29756 JQ772120 AFK29757 XM_005248130 XP_005248187 XM_005248131 XP_005248188 XM_005248132 XP_005248189 XM_005248134 XP_005248191 XM_011513764 XP_011512066 XM_011513765 XP_011512067 XM_011513766 XP_011512068 XM_011513767 XP_011512069 XM_011513768 XP_011512070 XM_011513769 XP_011512071 XM_011513770 XP_011512072 XM_011513771 XP_011512073 NM_013261 NP_037393
|
| Function |
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. {ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23836911}.
|
| Subcellular Location |
Isoform 9: Nucleus {ECO:0000269|PubMed:22009745}.
|
| Tissue Specificity |
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. {ECO:0000269|PubMed:10585775, ECO:0000269|PubMed:10643692, ECO:0000269|PubMed:10713165}.
|
| Top Pathways |
Insulin signaling pathway, Adipocytokine signaling pathway, Huntington's disease, AMPK signaling pathway, Glucagon signaling pathway
|
