Gene Symbol | CCBL1 |
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Entrez Gene | 883 |
Alt Symbol | GTK, KAT1, KATI |
Species | Human |
Gene Type | protein-coding |
Description | cysteine conjugate-beta lyase, cytoplasmic |
Other Description | beta-lysase, kidney|cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)|cysteine-S-conjugate beta-lyase|glutamine transaminase K|glutamine--phenylpyruvate transaminase|glutamine-phenylpyruvate aminotransferase|kyneurenine aminotransferase|kynurenine aminotransferase I|kynurenine--oxoglutarate transaminase 1|kynurenine--oxoglutarate transaminase I |
Swissprots | Q16773 Q8N191 Q5T275 |
Accessions | CAB44342 CAB44343 EAW87840 EAW87841 Q16773 AK094505 BAG52878 AK291178 BAF83867 AK297995 BAH12701 AK314427 BAG37043 AU123740 AW073815 BC013069 BC021262 AAH21262 BC022468 BC033685 AAH33685 BI755163 BM692880 BU622726 DA381449 DC413592 EL733697 X82224 CAA57702 XM_006717311 XP_006717374 XM_011519165 XP_011517467 XM_011519166 XP_011517468 XM_011519167 XP_011517469 XM_011519168 XP_011517470 XM_011519169 XP_011517471 XM_011519170 XP_011517472 XR_929870 NM_001122671 NP_001116143 NM_001122672 NP_001116144 NM_001287390 NP_001274319 NM_004059 NP_004050 NR_109829 |
Function | Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. {ECO:0000269|PubMed:19338303}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Chemical carcinogenesis, Selenocompound metabolism, Tryptophan metabolism |
KAT I CRISPR/Cas9 KO Plasmid (h) - sc-408115 from Santa Cruz Biotechnology
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KAT I HDR Plasmid (h) - sc-408115-HDR from Santa Cruz Biotechnology
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KAT I Double Nickase Plasmid (h) - sc-408115-NIC from Santa Cruz Biotechnology
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KAT I Double Nickase Plasmid (h2) - sc-408115-NIC-2 from Santa Cruz Biotechnology
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KAT I CRISPR Activation Plasmid (h) - sc-408115-ACT from Santa Cruz Biotechnology
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KAT I CRISPR Activation Plasmid (h2) - sc-408115-ACT-2 from Santa Cruz Biotechnology
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KAT I Lentiviral Activation Particles (h) - sc-408115-LAC from Santa Cruz Biotechnology
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KAT I Lentiviral Activation Particles (h2) - sc-408115-LAC-2 from Santa Cruz Biotechnology
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KAT I siRNA (h) - sc-105587 from Santa Cruz Biotechnology
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KAT I shRNA Plasmid (h) - sc-105587-SH from Santa Cruz Biotechnology
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KAT I shRNA (h) Lentiviral Particles - sc-105587-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5441 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05281 from Sigma-Aldrich
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CCBL1 siRNA (Human) - CRH0620 from Cohesion Biosciences
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CCBL1 - MBS8211676 from MyBioSource
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shRNA set against Human CCBL1 (NM_004059.4) - SHH255669 from Creative biogene
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shRNA set against Human CCBL1(NM_004059.4) - SHG145927 from Creative biogene
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Human CCBL1 siRNA - orb261122 from Biorbyt
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CCBL1 shRNA Plasmid (Human) - CHH0620 from Cohesion Biosciences
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CCBL1 miRNA 3'UTR clone - MiUTR1H-01715 from Creative biogene
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CCBL1 miRNA 3'UTR clone - MiUTR3H-03463 from Creative biogene
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CCBL1 miRNA 3'UTR clone - MiUTR3H-03464 from Creative biogene
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