| Gene Symbol |
IHH
|
| Entrez Gene |
3549
|
| Alt Symbol |
BDA1, HHG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
indian hedgehog
|
| Other Description |
HHG-2|Indian hedgehog homolog|indian hedgehog protein
|
| Swissprots |
Q8N4B9 Q14623 O43322 B9EGM5
|
| Accessions |
AAX88920 BAA33523 BAA36285 CAJ18810 CAM31803 EAW70675 Q14623 AI802733 BC034757 AAH34757 BC136587 AAI36588 BC136588 AAI36589 L38517 AAA62178 NM_002181 NP_002172
|
| Function |
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21537345}.
|
| Tissue Specificity |
Expressed in embryonic lung, and in adult kidney and liver.
|
| Top Pathways |
Hedgehog signaling pathway
|