Gene Symbol | IHH |
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Entrez Gene | 3549 |
Alt Symbol | BDA1, HHG2 |
Species | Human |
Gene Type | protein-coding |
Description | indian hedgehog |
Other Description | HHG-2|Indian hedgehog homolog|indian hedgehog protein |
Swissprots | Q8N4B9 Q14623 O43322 B9EGM5 |
Accessions | AAX88920 BAA33523 BAA36285 CAJ18810 CAM31803 EAW70675 Q14623 AI802733 BC034757 AAH34757 BC136587 AAI36588 BC136588 AAI36589 L38517 AAA62178 NM_002181 NP_002172 |
Function | Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21537345}. |
Tissue Specificity | Expressed in embryonic lung, and in adult kidney and liver. |
Top Pathways | Hedgehog signaling pathway |
Ihh CRISPR/Cas9 KO Plasmid (h) - sc-401466 from Santa Cruz Biotechnology
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Ihh HDR Plasmid (h) - sc-401466-HDR from Santa Cruz Biotechnology
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Ihh Double Nickase Plasmid (h) - sc-401466-NIC from Santa Cruz Biotechnology
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Ihh Double Nickase Plasmid (h2) - sc-401466-NIC-2 from Santa Cruz Biotechnology
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Ihh CRISPR Activation Plasmid (h) - sc-401466-ACT from Santa Cruz Biotechnology
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Ihh CRISPR Activation Plasmid (h2) - sc-401466-ACT-2 from Santa Cruz Biotechnology
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Ihh Lentiviral Activation Particles (h) - sc-401466-LAC from Santa Cruz Biotechnology
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Ihh Lentiviral Activation Particles (h2) - sc-401466-LAC-2 from Santa Cruz Biotechnology
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Ihh siRNA (h) - sc-37206 from Santa Cruz Biotechnology
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Ihh shRNA Plasmid (h) - sc-37206-SH from Santa Cruz Biotechnology
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Ihh shRNA (h) Lentiviral Particles - sc-37206-V from Santa Cruz Biotechnology
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Indian Hedgehog/Ihh RNAi - H00003549-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10549 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10549 from Sigma-Aldrich
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IHH siRNA (Human) - CRH2368 from Cohesion Biosciences
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IHH - MBS8212578 from MyBioSource
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shRNA set against Human IHH (NM_002181.3) - SHH317949 from Creative biogene
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Human IHH siRNA - orb262870 from Biorbyt
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IHH shRNA Plasmid (Human) - CHH2368 from Cohesion Biosciences
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IHH miRNA 3'UTR clone - MiUTR4H-TG04457 from Creative biogene
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