Gene Symbol | FRG1 |
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Entrez Gene | 2483 |
Alt Symbol | FRG1A, FSG1 |
Species | Human |
Gene Type | protein-coding |
Description | FSHD region gene 1 |
Other Description | FSHD region gene 1 protein|facioscapulohumeral muscular dystrophy region gene-1|protein FRG1 |
Swissprots | Q14331 A8K775 |
Accessions | AAD46768 EAX04600 Q14331 AA749391 AK291890 BAF84579 BC053997 AAH53997 BG426031 HQ448060 ADQ32541 L76159 AAA95939 XR_938715 XR_952267 NM_004477 NP_004468 |
Function | Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase SUV420H1. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15060122, ECO:0000269|PubMed:20970242, ECO:0000269|PubMed:21699900, ECO:0000269|PubMed:23720823}. |
Subcellular Location | Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post- differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation. |
Tissue Specificity | Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis. {ECO:0000269|PubMed:20970242}. |
Human FRG1 full length protein - ab158466 from Abcam
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Human FRG1 protein fragment - ab158467 from Abcam
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FRG1 Antibody Blocking Peptide - LS-E4370 from LifeSpan Bioscience
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FRG1 Antibody Blocking Peptide - LS-E19725 from LifeSpan Bioscience
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FRG1 Antibody Blocking Peptide - LS-E19726 from LifeSpan Bioscience
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FRG1 Antibody Blocking Peptide - LS-E27326 from LifeSpan Bioscience
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Recombinant Human FRG1 Protein - H00002483-Q01 from Novus Biologicals
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Recombinant Human FRG1 Protein - H00002483-P01 from Novus Biologicals
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FRG1-Antibody-C-term-Blocking-Peptide - BP16673b from Abgent, a WuXi AppTec company
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FRG1 blocking peptide - GTX88126-PEP from GeneTex
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FRG1 Peptide - AC21-2150-P from Abcore
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FRG1 - H00002483-P01-10 from Acris Antibodies
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FRG1 - H00002483-P01-25 from Acris Antibodies
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FRG1 - H00002483-Q01-10 from Acris Antibodies
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FRG1 - H00002483-Q01-25 from Acris Antibodies
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FRG1 Peptide - 42-552P from ProSci
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FRG1 fusion protein - Ag6163 from Proteintech Group
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Recombinant Human FRG1, His-tagged - FRG1-13002H from Creative Biomart
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Recombinant Human Protein FRG1(FRG1) - CSB-YP623915HU CSB-EP623915HU CSB-BP623915HU CSB-MP623915HU from Cusabio
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FRG1 - TP308772 from Acris Antibodies
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FRG1, Peptide - MBS427260 from MyBioSource
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FRG1 Peptide, Human - M34GP05897H from Creative Peptides
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Protein FRG1 (FRG1), Recombinant Protein - MBS1307086 from MyBioSource
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