Gene Symbol | Eng |
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Entrez Gene | 13805 |
Alt Symbol | AI528660, AI662476, CD105, Endo, S-endoglin |
Species | Mouse |
Gene Type | protein-coding |
Description | endoglin |
Other Description | cell surface MJ7/18 antigen|transmembrane glycoprotein |
Swissprots | Q8K100 Q63961 Q61520 |
Accessions | EDL08562 Q63961 AK018588 AK151302 BAE30285 AK164727 AK178235 AK178966 AK180986 AK183292 AK187426 AK187802 AK188120 AK196985 AK198539 AK199423 AY679531 AAT81170 BB851508 BC029080 AAH29080 BY226445 EU330531 ABY49139 S69407 AAB30196 X77952 CAA54917 XM_006497663 XP_006497726 XM_006497664 XP_006497727 NM_001146348 NP_001139820 NM_001146350 NP_001139822 NM_007932 NP_031958 |
Function | Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. {ECO:0000269|PubMed:23300529}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus. |
Endoglin CRISPR/Cas9 KO Plasmid (m) - sc-420177 from Santa Cruz Biotechnology
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Endoglin HDR Plasmid (m) - sc-420177-HDR from Santa Cruz Biotechnology
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Endoglin Double Nickase Plasmid (m) - sc-420177-NIC from Santa Cruz Biotechnology
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Endoglin Double Nickase Plasmid (m2) - sc-420177-NIC-2 from Santa Cruz Biotechnology
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Endoglin CRISPR Activation Plasmid (m) - sc-420177-ACT from Santa Cruz Biotechnology
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Endoglin CRISPR Activation Plasmid (m2) - sc-420177-ACT-2 from Santa Cruz Biotechnology
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Endoglin Lentiviral Activation Particles (m) - sc-420177-LAC from Santa Cruz Biotechnology
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Endoglin Lentiviral Activation Particles (m2) - sc-420177-LAC-2 from Santa Cruz Biotechnology
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Endoglin siRNA (m) - sc-35303 from Santa Cruz Biotechnology
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Endoglin shRNA Plasmid (m) - sc-35303-SH from Santa Cruz Biotechnology
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Endoglin shRNA (m) Lentiviral Particles - sc-35303-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU049831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30643 from Sigma-Aldrich
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ENG siRNA (Mouse) - CRM1200 from Cohesion Biosciences
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ENG - MBS8211199 from MyBioSource
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shRNA set against Mouse ENG (NM_007932.2) - SHH285773 from Creative biogene
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ENG shRNA Plasmid (Mouse) - CHM1200 from Cohesion Biosciences
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