| Gene Symbol |
TFDP1
|
| Entrez Gene |
7027
|
| Alt Symbol |
DP1, DRTF1, Dp-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor Dp-1
|
| Other Description |
DRTF1-polypeptide 1|E2F dimerization partner 1|E2F-related transcription factor
|
| Swissprots |
Q5JSB4 Q14186 B4DLQ9 Q8IZL5
|
| Accessions |
AAN46090 EAX09216 EAX09217 EAX09218 EAX09219 Q14186 AK297114 BAG59621 AK298521 BAH12805 AK310401 AK313742 BC011685 AAH11685 BC036601 CD623680 DQ589756 DQ892865 ABM83791 DQ896114 ABM87113 L23959 AAA58440 XM_005268326 XP_005268383 XM_005268327 XP_005268384 XM_005268328 XP_005268385 XM_005268330 XP_005268387 XM_005268331 XP_005268388 XM_011537518 XP_011535820 XM_011537519 XP_011535821 XM_011537520 XP_011535822 NM_007111 NP_009042 NR_026580
|
| Function |
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
|
| Top Pathways |
Cell cycle, TGF-beta signaling pathway
|