| Gene Symbol |
ZBTB17
|
| Entrez Gene |
7709
|
| Alt Symbol |
MIZ-1, ZNF151, ZNF60, pHZ-67
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger and BTB domain containing 17
|
| Other Description |
Myc-interacting Zn finger protein-1|zinc finger and BTB domain-containing protein 17|zinc finger protein 151 (pHZ-67)|zinc finger protein 60
|
| Swissprots |
Q15932 F5H411 A0AV07 Q13105 B4DXB4 B7ZLQ9 Q9NUC9 Q5JYB2
|
| Accessions |
AAA61327 EAW51757 EAW51758 Q13105 AK223618 BAD97338 AK226168 AK294796 BAG57917 AK299820 BAG61689 AK301896 BAG63326 AK302610 BAG63857 AK303823 BAG64771 AK309081 AK311083 AK315201 BAG37639 BC126163 AAI26164 BC143965 AAI43966 BC143968 BQ575263 BU634371 DB064089 U20647 AAC50256 Y09723 CAA70889 XM_005245986 XP_005246043 XM_005245987 XP_005246044 XM_011542085 XP_011540387 XM_011542086 XP_011540388 XM_011542087 XP_011540389 XM_011542088 XP_011540390 XM_011542089 XP_011540391 NM_001242884 NP_001229813 NM_001287603 NP_001274532 NM_001287604 NP_001274533 NM_003443 NP_003434
|
| Function |
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14739298, ECO:0000269|PubMed:9312026}.
|
| Tissue Specificity |
Expressed in germinal center B-cells. {ECO:0000269|PubMed:16142238}.
|
| Top Pathways |
Cell cycle, Transcriptional misregulation in cancer
|