ZBTB17

Gene Symbol ZBTB17
Entrez Gene 7709
Alt Symbol MIZ-1, ZNF151, ZNF60, pHZ-67
Species Human
Gene Type protein-coding
Description zinc finger and BTB domain containing 17
Other Description Myc-interacting Zn finger protein-1|zinc finger and BTB domain-containing protein 17|zinc finger protein 151 (pHZ-67)|zinc finger protein 60
Swissprots Q15932 F5H411 A0AV07 Q13105 B4DXB4 B7ZLQ9 Q9NUC9 Q5JYB2
Accessions AAA61327 EAW51757 EAW51758 Q13105 AK223618 BAD97338 AK226168 AK294796 BAG57917 AK299820 BAG61689 AK301896 BAG63326 AK302610 BAG63857 AK303823 BAG64771 AK309081 AK311083 AK315201 BAG37639 BC126163 AAI26164 BC143965 AAI43966 BC143968 BQ575263 BU634371 DB064089 U20647 AAC50256 Y09723 CAA70889 XM_005245986 XP_005246043 XM_005245987 XP_005246044 XM_011542085 XP_011540387 XM_011542086 XP_011540388 XM_011542087 XP_011540389 XM_011542088 XP_011540390 XM_011542089 XP_011540391 NM_001242884 NP_001229813 NM_001287603 NP_001274532 NM_001287604 NP_001274533 NM_003443 NP_003434
Function Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}.
Subcellular Location Nucleus {ECO:0000269|PubMed:14739298, ECO:0000269|PubMed:9312026}.
Tissue Specificity Expressed in germinal center B-cells. {ECO:0000269|PubMed:16142238}.
Top Pathways Cell cycle, Transcriptional misregulation in cancer

SignalSilence ® Miz-1 siRNA II - 12405 from Cell Signaling Technology

Category siRNA
Prices $249.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from HaCaT cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® Miz-1 siRNA I #12335 (+), or SignalSilence ® Miz-1 siRNA II (+), using Miz-1 Antibody #9044 (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The Miz-1 Antibody confirms silencing of Miz-1 expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.

SignalSilence ® Miz-1 siRNA I - 12335 from Cell Signaling Technology

Category siRNA
Prices $249.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from HaCaT cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® Miz-1 siRNA I (+), or SignalSilence ® Miz-1 siRNA II #12405 (+), using Miz-1 Antibody #9044 (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The Miz-1 Antibody confirms silencing of Miz-1 expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.

Miz-1 CRISPR/Cas9 KO Plasmid (h) - sc-402110 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 HDR Plasmid (h) - sc-402110-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 Double Nickase Plasmid (h) - sc-402110-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 Double Nickase Plasmid (h2) - sc-402110-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 CRISPR Activation Plasmid (h) - sc-402110-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 CRISPR Activation Plasmid (h2) - sc-402110-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 Lentiviral Activation Particles (h) - sc-402110-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 Lentiviral Activation Particles (h2) - sc-402110-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 siRNA (h) - sc-38085 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Miz-1 shRNA Plasmid (h) - sc-38085-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Miz-1 shRNA (h) Lentiviral Particles - sc-38085-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU015691 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23058 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23058 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ZBTB17 siRNA (Human) - CRH5226 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Miz-1/ZBTB17 RNAi - H00007709-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ZBTB17 - MBS8235885 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Miz-1 CRISPR/Cas9 KO Plasmid (h2) - sc-402110-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Miz-1 HDR Plasmid (h2) - sc-402110-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human ZBTB17 (NM_003443.2) - SHH448956 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ZBTB17(NM_003443.2) - SHL141744 from Creative biogene

Category siRNA
Species Reactivities Human

Human ZBTB17 siRNA - orb265728 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZBTB17 shRNA Plasmid (Human) - CHH5226 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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