| Gene Symbol |
NUDT18
|
| Entrez Gene |
79873
|
| Alt Symbol |
MTH3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 18
|
| Other Description |
2-hydroxy-dADP phosphatase|7,8-dihydro-8-oxoguanine phosphatase|8-oxo-dGDP phosphatase NUDT18|mutT homolog 3|mutT human homolog 3|nucleoside diphosphate-linked moiety X motif 18|nudix motif 18
|
| Swissprots |
Q8IZ75 Q9H687 Q6ZVK8
|
| Accessions |
EAW63719 Q6ZVK8 AK026147 BAB15376 AK124446 BAC85853 BC016902 AAH16902 DA015404 HQ447874 ADQ32358 XM_011544650 XP_011542952 NM_024815 NP_079091
|
| Function |
Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. {ECO:0000269|PubMed:22556419}.
|