Gene Symbol | NUDT18 |
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Entrez Gene | 79873 |
Alt Symbol | MTH3 |
Species | Human |
Gene Type | protein-coding |
Description | nudix (nucleoside diphosphate linked moiety X)-type motif 18 |
Other Description | 2-hydroxy-dADP phosphatase|7,8-dihydro-8-oxoguanine phosphatase|8-oxo-dGDP phosphatase NUDT18|mutT homolog 3|mutT human homolog 3|nucleoside diphosphate-linked moiety X motif 18|nudix motif 18 |
Swissprots | Q8IZ75 Q9H687 Q6ZVK8 |
Accessions | EAW63719 Q6ZVK8 AK026147 BAB15376 AK124446 BAC85853 BC016902 AAH16902 DA015404 HQ447874 ADQ32358 XM_011544650 XP_011542952 NM_024815 NP_079091 |
Function | Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. {ECO:0000269|PubMed:22556419}. |
NUDT18 CRISPR/Cas9 KO Plasmid (h) - sc-413280 from Santa Cruz Biotechnology
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NUDT18 HDR Plasmid (h) - sc-413280-HDR from Santa Cruz Biotechnology
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NUDT18 Double Nickase Plasmid (h) - sc-413280-NIC from Santa Cruz Biotechnology
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NUDT18 Double Nickase Plasmid (h2) - sc-413280-NIC-2 from Santa Cruz Biotechnology
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NUDT18 CRISPR Activation Plasmid (h) - sc-413280-ACT from Santa Cruz Biotechnology
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NUDT18 CRISPR Activation Plasmid (h2) - sc-413280-ACT-2 from Santa Cruz Biotechnology
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NUDT18 Lentiviral Activation Particles (h) - sc-413280-LAC from Santa Cruz Biotechnology
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NUDT18 Lentiviral Activation Particles (h2) - sc-413280-LAC-2 from Santa Cruz Biotechnology
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NUDT18 siRNA (h) - sc-77648 from Santa Cruz Biotechnology
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NUDT18 shRNA Plasmid (h) - sc-77648-SH from Santa Cruz Biotechnology
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NUDT18 shRNA (h) Lentiviral Particles - sc-77648-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU044711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15597 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15597 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03513 from Sigma-Aldrich
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NUDT18 siRNA (Human) - CRJ2631 from Cohesion Biosciences
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shRNA set against Human NUDT18 (NM_024815.3) - SHH356124 from Creative biogene
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shRNA set against Human NUDT18(NM_024815.3) - SHR025552 from Creative biogene
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Human NUDT18 siRNA - orb273132 from Biorbyt
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NUDT18 shRNA Plasmid (Human) - CHJ2631 from Cohesion Biosciences
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NUDT18 miRNA 3'UTR clone - MiUTR1H-06969 from Creative biogene
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