WASF2

Gene Symbol WASF2
Entrez Gene 10163
Alt Symbol IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2
Species Human
Gene Type protein-coding
Description WAS protein family, member 2
Other Description WASP family Verprolin-homologous protein 2|WASP family protein member 2|WASP family protein member 4|protein WAVE-2|putative Wiskott-Aldrich syndrome protein family member 4|suppressor of cyclic-AMP receptor (WASP-family)|verprolin homology domain-containing protein 2|wiskott-Aldrich syndrome protein family member 2
Swissprots Q9UDY7 B4DZN0 O60794 Q9Y6W5
Accessions CAC18518 EAX07753 Q9Y6W5 AA736923 AB026542 BAA81795 AJ431612 AK024540 AK025566 AK075231 BAC11488 AK303011 BAG64142 AK304750 BAG65507 AY007122 BC001524 BC001855 BC012329 BC032380 BC032724 AAH32724 BC040943 AAH40943 DC300388 DC376823 HY001891 NM_001201404 NP_001188333 NM_006990 NP_008921
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
Tissue Specificity Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. {ECO:0000269|PubMed:10381382}.
Top Pathways Adherens junction, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Choline metabolism in cancer

WAVE-2 (D2C8) XP ® Rabbit mAb - 3659 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2C8
Western blot analysis of extracts from various cell types using WAVE-2 (D2C8) XP ® Rabbit mAb.

WAVE2 (C-6) - sc-373889 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WAVE2 (C-6): sc-373889. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

WAVE2 (C-14) - sc-10394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WAVE2 (C-14): sc-10394. Western blot analysis of WAVE2 expression in MOLT-4 (A), AML-193 (B) and CCRF-CEM (C) whole cell lysates.

WAVE2 (D-16) - sc-10392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WAVE2 (D-16): sc-10392. Western blot analysis of WAVE2 expression in MOLT-4 (A), AML-193 (B) and CCRF-CEM (C) whole cell lysates.

WAVE2 (H-110) - sc-33548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
WAVE2 (H-110): sc-33548. Western blot analysis of WAVE2 expression in MOLT-4 whole cell lysate.

Anti-WASF2 antibody - ab60722 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing K562 cells stained with ab60722 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab60722, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in K562 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-WASF2 antibody - ab167056 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human lung tissue labeling WASF2 with ab167056 at 5µg/ml.

Anti-WASF2 antibody [EPR12105] - ab173582 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12105
Immunohistochemical analysis of paraffin-embedded Human placenta tissue labeling WASF2 with ab173582 at 1/100 dilution

Anti-WASF2 antibody - C-terminal - ab197189 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-WASF2 antibody - C-terminal (ab197189) at 1/500 dilution + HeLa cell lysate

Anti-WASF2 / SCAR2 Antibody (aa141-190) - LS-C291427 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (aa161-190) - LS-C326314 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (aa162-190, PE) - LS-C207861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCAR2 / WAVE2 Antibody (aa73-173, Azide-free) - LS-C329095 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-WASF2 / SCAR2 Antibody (aa162-190) - LS-C160566 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
WASF2 Antibody western blot of HeLa cell line lysates (35 ug/lane). The WASF2 antibody detected the WASF2 protein (arrow).

Anti-WASF2 / SCAR2 Antibody (clone 1F7) - LS-C139315 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F7
WASF2 monoclonal antibody (M01), clone 1F7. Western blot of WASF2 expression in HeLa.

Anti-WASF2 / SCAR2 Antibody (aa190-239) IHC-plus™ - LS-B8597 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SCAR2 / WAVE2 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8597 dilution 5 ug/ml.

Anti-WASF2 / SCAR2 Antibody (aa186-200) - LS-C18543 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (Internal) - LS-C132940 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (phospho-Ser343) - LS-C190162 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (aa231-280) - LS-C151266 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SCAR2 / WAVE2 antibody Western Blot of Mouse Thymus.

Anti-WASF2 / SCAR2 Antibody (aa146-195) - LS-C135254 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WASF2 antibody LS-C135254 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-WASF2 / SCAR2 Antibody (aa162-190, APC) - LS-C207856 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (aa162-190, AP) - LS-C207855 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (aa162-190, Biotin) - LS-C207857 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WASF2 / SCAR2 Antibody (aa162-190, FITC) - LS-C207858 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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