Gene Symbol | WASF2 |
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Entrez Gene | 10163 |
Alt Symbol | IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2 |
Species | Human |
Gene Type | protein-coding |
Description | WAS protein family, member 2 |
Other Description | WASP family Verprolin-homologous protein 2|WASP family protein member 2|WASP family protein member 4|protein WAVE-2|putative Wiskott-Aldrich syndrome protein family member 4|suppressor of cyclic-AMP receptor (WASP-family)|verprolin homology domain-containing protein 2|wiskott-Aldrich syndrome protein family member 2 |
Swissprots | Q9UDY7 B4DZN0 O60794 Q9Y6W5 |
Accessions | CAC18518 EAX07753 Q9Y6W5 AA736923 AB026542 BAA81795 AJ431612 AK024540 AK025566 AK075231 BAC11488 AK303011 BAG64142 AK304750 BAG65507 AY007122 BC001524 BC001855 BC012329 BC032380 BC032724 AAH32724 BC040943 AAH40943 DC300388 DC376823 HY001891 NM_001201404 NP_001188333 NM_006990 NP_008921 |
Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}. |
Tissue Specificity | Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. {ECO:0000269|PubMed:10381382}. |
Top Pathways | Adherens junction, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Choline metabolism in cancer |
Human WASF2 full length protein - ab160851 from Abcam
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Human WASF2 protein fragment - ab160852 from Abcam
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Recombinant Human WASF2 Protein - H00010163-P01 from Novus Biologicals
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Recombinant Human WASF2 Protein - H00010163-Q01 from Novus Biologicals
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WASF2-Antibody-Center-Blocking-Peptide - BP14540c from Abgent, a WuXi AppTec company
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WASF2 / WAVE2 - H00010163-P01-10 from Acris Antibodies
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WASF2 / WAVE2 - H00010163-P01-25 from Acris Antibodies
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WASF2 / WAVE2 - H00010163-Q01-10 from Acris Antibodies
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WASF2 / WAVE2 - H00010163-Q01-25 from Acris Antibodies
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Recombinant Human WASF2 protein, MYC/DDK-tagged - WASF2-1183H from Creative Biomart
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Recombinant Human WASF2 protein, GST-tagged - WASF2-1839H from Creative Biomart
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Recombinant Human WASF2 protein, GST-tagged - WASF2-1832H from Creative Biomart
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Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) - RPE773Hu01 from Uscn Life Science Inc.
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Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) - RPE773Mu01 from Uscn Life Science Inc.
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Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) - RPE773Mu02 from Uscn Life Science Inc.
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Recombinant Human Wiskott-Aldrich syndrome protein family member 2(WASF2) - CSB-YP896553HU CSB-EP896553HU CSB-BP896553HU CSB-MP896553HU from Cusabio
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WAVE2 (Central region) - WX1795 from ECM Biosciences
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WASF2 / WAVE2 - TP308034 from Acris Antibodies
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Wiskott-Aldrich syndrome protein family member 2 (WASF2) , Recombinant Protein - MBS1285525 from MyBioSource
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WAVE2 (Central region) Peptide, Peptide - MBS474071 from MyBioSource
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WASF2 Protein - NBP2-37912PEP from Novus Biologicals
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WASF2 Peptide, Human - M34GP17378H from Creative Peptides
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