| Gene Symbol |
GNL3L
|
| Entrez Gene |
54552
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide binding protein-like 3 (nucleolar)-like
|
| Other Description |
guanine nucleotide-binding protein-like 3-like protein|novel GTPase
|
| Swissprots |
Q9NVN8
|
| Accessions |
CAE89448 CBX47629 EAW93182 EAW93183 EAW93184 EAW93185 Q9NVN8 AK001475 BAA91712 AK022325 AK128277 BC003603 AAH03603 BC011720 AAH11720 BC022829 BQ674906 XM_011530799 XP_011529101 NM_001184819 NP_001171748 NM_019067 NP_061940
|
| Function |
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:17034816}.
|
| Top Pathways |
Ribosome biogenesis in eukaryotes
|
![Western Blot: GNL3L Overexpression Lysate (Adult Normal) [NBP2-04539] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GNL3L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4185_GNL3L%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04539-img0001.jpg)