GNL3L

Gene Symbol GNL3L
Entrez Gene 54552
Alt Symbol -
Species Human
Gene Type protein-coding
Description guanine nucleotide binding protein-like 3 (nucleolar)-like
Other Description guanine nucleotide-binding protein-like 3-like protein|novel GTPase
Swissprots Q9NVN8
Accessions CAE89448 CBX47629 EAW93182 EAW93183 EAW93184 EAW93185 Q9NVN8 AK001475 BAA91712 AK022325 AK128277 BC003603 AAH03603 BC011720 AAH11720 BC022829 BQ674906 XM_011530799 XP_011529101 NM_001184819 NP_001171748 NM_019067 NP_061940
Function Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:17034816}.
Top Pathways Ribosome biogenesis in eukaryotes

Anti-GNL3L antibody - ab94862 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of HeLa cells labelling GNL3L with ab94862 at 1/250. Cells wew fixed with 4% PFA for 30 minutes and blocked with 5% goat serum + 1% BSA + 0.02% fish gelatin overnight at 4°C. Cells were incubated with the primary antibody overnight at 4°C. An Alexa Fluor 546-conjugated anti-rabbit IgG (1/500, room temperature, 2 hours) was used as the secondary antibody.

Anti-GNL3L antibody - ab94861 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GNL3L antibody (ab94861) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal lung lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-GNL3L Antibody (aa102-130) - LS-C166564 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GNL3L Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The GNL3L antibody detected the GNL3L protein (arrow).

Anti-GNL3L Antibody (aa102-130, APC) - LS-C235830 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa102-130, AP) - LS-C235828 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa102-130, Biotin) - LS-C235831 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa102-130, FITC) - LS-C235832 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa102-130, PE) - LS-C235833 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa102-130, Azide-free, HRP) - LS-C249100 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (N-Terminus) - LS-C110922 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GNL3L antibody LS-C110922 Western blot of Fetal Lung lysate.

Anti-GNL3L Antibody (aa102-130) - LS-C321695 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa57-106) - LS-C292000 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GNL3L Antibody (aa71-120) - LS-C110923 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GNL3L antibody LS-C110923 Western blot of Fetal Lung lysate.

Anti-GNL3L Antibody (aa71-120) - LS-C120034 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from 293/HeLa/HT-29 cells, using GNL3L Antibody. The lane on the right is treated with the synthesized peptide.

GNL3L Antibody - NBP2-32660 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GNL3L Antibody [NBP2-32660] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-245

GNL3L Antibody - NBP1-84618 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Antibody - NBP1-55241 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GNL3L Antibody [NBP1-55241] - Analysis of 721_B cell lysate. Antibody Dilution: 1.0 ug/ml GNL3L is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells.

GNL3L Antibody - NBP1-55240 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody - bs-13472R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13472R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13472R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13472R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13472R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody, Cy3 Conjugated - bs-13472R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GNL3L Polyclonal Antibody, Cy5 Conjugated - bs-13472R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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