| Gene Symbol |
LEPROT
|
| Entrez Gene |
54741
|
| Alt Symbol |
LEPR, OB-RGRP, OBRGRP, VPS55
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leptin receptor overlapping transcript
|
| Other Description |
DnaJ (Hsp40) homolog, subfamily C, member 6|OB-R gene-related protein|endospanin-1|leptin receptor gene related protein|leptin receptor gene-related protein|leptin receptor overlapping transcript protein
|
| Swissprots |
Q6FHL5 O15243
|
| Accessions |
CAF86819 CAH25980 CAH59519 CBX85065 EAX06527 EAX06531 O15243 AK023598 AK026175 AK074841 BAG52014 AK094801 AK130096 AK309370 BC011027 AAH11027 BC036581 BC056250 AAH56250 BC140007 BI715133 BU677319 BX360952 CA434795 CB140261 CR541647 CAG46448 CR541737 CAG46537 EU832353 ACE87610 EU832438 ACE86923 Y12670 CAA73211 NM_001198681 NP_001185610 NM_001198683 NP_001185612 NM_017526 NP_059996
|
| Function |
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
|
| Tissue Specificity |
Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
|