Gene Symbol | LEPROT |
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Entrez Gene | 54741 |
Alt Symbol | LEPR, OB-RGRP, OBRGRP, VPS55 |
Species | Human |
Gene Type | protein-coding |
Description | leptin receptor overlapping transcript |
Other Description | DnaJ (Hsp40) homolog, subfamily C, member 6|OB-R gene-related protein|endospanin-1|leptin receptor gene related protein|leptin receptor gene-related protein|leptin receptor overlapping transcript protein |
Swissprots | Q6FHL5 O15243 |
Accessions | CAF86819 CAH25980 CAH59519 CBX85065 EAX06527 EAX06531 O15243 AK023598 AK026175 AK074841 BAG52014 AK094801 AK130096 AK309370 BC011027 AAH11027 BC036581 BC056250 AAH56250 BC140007 BI715133 BU677319 BX360952 CA434795 CB140261 CR541647 CAG46448 CR541737 CAG46537 EU832353 ACE87610 EU832438 ACE86923 Y12670 CAA73211 NM_001198681 NP_001185610 NM_001198683 NP_001185612 NM_017526 NP_059996 |
Function | Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}. |
Tissue Specificity | Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas. |
LEPR / Leptin Receptor Antibody Blocking Peptide - LS-E4793 from LifeSpan Bioscience
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LEPR / Leptin Receptor Antibody Blocking Peptide - LS-E26104 from LifeSpan Bioscience
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Recombinant Human Leptin R Protein - H00003953-Q01 from Novus Biologicals
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Recombinant Human Leptin R Protein - H00003953-G01 from Novus Biologicals
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Leptin Receptor, Human Recombinant - 228-11033-1 from RayBiotech
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Recombinant Chicken LEPR - 228-11033-2 from RayBiotech
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Recombinant Chicken LEPR - 228-11033-3 from RayBiotech
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LEPROT fusion protein - ag2588 from Proteintech Group
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LEPROT fusion protein - ag14451 from Proteintech Group
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LEPROT fusion protein - ag14126 from Proteintech Group
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Recombinant Human LEPR - LEPR-29427TH from Creative Biomart
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LEPR - PN201771 from Elabscience
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Human Leptin Receptor / LEPR / CD295 Protein (His & Fc Tag) - 10322-H03H-100 from Sino Biological
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Human Leptin Receptor / LEPR / CD295 Protein (His Tag) - 10322-H08H-100 from Sino Biological
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Human Leptin R / CD295 Protein, Fc Tag - LER-H5252 from ACROBiosystems
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Leptin Receptor B, Peptide - MBS633710 from MyBioSource
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Leptin Receptor B,, Peptide - MBS633680 from MyBioSource
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Recombinant Human Leptin Receptor / LEPR / CD295 Protein (His tag) - PKSH031688 from Elabscience
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Recombinant Human Leptin Receptor / LEPR / CD295 Protein (His & Fc tag) - PKSH031689 from Elabscience
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Leptin R Recombinant Protein Antigen - NBP1-85765PEP from Novus Biologicals
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LEPR Peptide, Human - M34GP08641H from Creative Peptides
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LEPROT Peptide, Human - M34GP08646H from Creative Peptides
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LEPROT Recombinant Protein Antigen - NBP2-57596PEP from Novus Biologicals
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LEPR, Recombinant Protein - MBS636524 from MyBioSource
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Leptin receptor gene-related protein (LEPROT), Recombinant Protein - MBS7018278 from MyBioSource
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