| Gene Symbol |
PPL
|
| Entrez Gene |
5493
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
periplakin
|
| Other Description |
190 kDa paraneoplastic pemphigus antigen|195 kDa cornified envelope precursor protein
|
| Swissprots |
Q14C98 O60437 O60314 O60454
|
| Accessions |
AAD17459 CAP07522 CAP11490 CAR97104 CAT82362 EAW85248 O60437 AB011140 BAA25494 AF001691 AAC17738 AF013717 AAC39668 AK295623 BAH12130 AW582622 BC114620 AAI14621 BM673980 XM_006720902 XP_006720965 NM_002705 NP_002696
|
| Function |
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}.
|
| Subcellular Location |
Cell junction, desmosome {ECO:0000269|PubMed:9412476}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9412476}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Associated with desmosomes and intermediate filaments.
|
| Tissue Specificity |
Expressed in stratified squamous epithelia and in some other epithelia. {ECO:0000269|PubMed:9412476, ECO:0000269|PubMed:9521878}.
|