Gene Symbol | PPL |
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Entrez Gene | 5493 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | periplakin |
Other Description | 190 kDa paraneoplastic pemphigus antigen|195 kDa cornified envelope precursor protein |
Swissprots | Q14C98 O60437 O60314 O60454 |
Accessions | AAD17459 CAP07522 CAP11490 CAR97104 CAT82362 EAW85248 O60437 AB011140 BAA25494 AF001691 AAC17738 AF013717 AAC39668 AK295623 BAH12130 AW582622 BC114620 AAI14621 BM673980 XM_006720902 XP_006720965 NM_002705 NP_002696 |
Function | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
Subcellular Location | Cell junction, desmosome {ECO:0000269|PubMed:9412476}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9412476}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Associated with desmosomes and intermediate filaments. |
Tissue Specificity | Expressed in stratified squamous epithelia and in some other epithelia. {ECO:0000269|PubMed:9412476, ECO:0000269|PubMed:9521878}. |
periplakin CRISPR/Cas9 KO Plasmid (h) - sc-402350 from Santa Cruz Biotechnology
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periplakin HDR Plasmid (h) - sc-402350-HDR from Santa Cruz Biotechnology
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periplakin Double Nickase Plasmid (h) - sc-402350-NIC from Santa Cruz Biotechnology
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periplakin Double Nickase Plasmid (h2) - sc-402350-NIC-2 from Santa Cruz Biotechnology
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periplakin CRISPR Activation Plasmid (h) - sc-402350-ACT from Santa Cruz Biotechnology
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periplakin CRISPR Activation Plasmid (h2) - sc-402350-ACT-2 from Santa Cruz Biotechnology
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periplakin Lentiviral Activation Particles (h) - sc-402350-LAC from Santa Cruz Biotechnology
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periplakin Lentiviral Activation Particles (h2) - sc-402350-LAC-2 from Santa Cruz Biotechnology
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periplakin siRNA (h) - sc-43414 from Santa Cruz Biotechnology
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periplakin shRNA Plasmid (h) - sc-43414-SH from Santa Cruz Biotechnology
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periplakin shRNA (h) Lentiviral Particles - sc-43414-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU053981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17239 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17239 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06950 from Sigma-Aldrich
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PPL siRNA (Human) - CRH3679 from Cohesion Biosciences
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shRNA set against Human PPL (NM_002705.4) - SHH380772 from Creative biogene
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shRNA set against Human PPL(NM_002705.4) - SHR132594 from Creative biogene
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Human PPL siRNA - orb264181 from Biorbyt
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PPL shRNA Plasmid (Human) - CHH3679 from Cohesion Biosciences
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PPL miRNA 3'UTR clone - MiUTR1H-08162 from Creative biogene
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