KPNA1

Gene Symbol	KPNA1
Entrez Gene	3836
Alt Symbol	IPOA5, NPI-1, RCH2, SRP1
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 1 (importin alpha 5)
Other Description	RAG cohort protein 2|SRP1-beta|importin alpha 5|importin subunit alpha-1|importin subunit alpha-5|importin-alpha-S1|karyopherin subunit alpha-1|nucleoprotein interactor 1|recombination activating gene cohort 2
Swissprots	Q6IBQ9 D3DN93 P52294 Q9BQ56
Accessions	CCQ43172 EAW79482 EAW79483 P52294 AA689229 AF035311 AI216375 AK125626 BAG54224 AK128280 BAG54654 AK299030 BAG61106 AK312713 AL700464 AL710311 BC002374 AAH02374 BC003009 AAH03009 BC029937 BC090864 AAH90864 BG287593 BT006959 AAP35605 CA433573 CR456743 CAG33024 DA308391 DN991078 DQ891406 ABM82332 DQ896822 ABM87821 S75295 AAC60648 U20620 XM_005247437 XP_005247494 XM_005247439 XP_005247496 XM_011512795 XP_011511097 XM_011512796 XP_011511098 XM_011512797 XP_011511099 NM_002264 NP_002255 NR_026698
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

karyopherin α1 (187.1) - sc-101292 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

karyopherin α1 (H-58) - sc-292777 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

karyopherin α1/6 (2D9) - sc-101540 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rat Clonality Monoclonal

karyopherin α1/6 (C-20) - sc-6918 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

karyopherin α2 (8G5) - sc-136204 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-SRP1 antibody - ab105346 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SRP1 antibody - ab55387 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SRP1 antibody - ab6035 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SRP1 antibody [2A4-1B5] - ab124646 from Abcam Prices $464.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2A4-1B5

Anti-KPNA1 / Importin Alpha 5 Antibody (clone 114-E12) - LS-C16999 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 114-E12

Anti-KPNA1 / Importin Alpha 5 Antibody - LS-C71259 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (aa2-14) - LS-C55041 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (clone 2498C2a) - LS-C184662 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2498C2a

Anti-KPNA1 / Importin Alpha 5 Antibody (aa74-123) - LS-C81900 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (N-Terminus) - LS-C81899 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody - LS-C308690 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (aa239-506, FITC) - LS-C302957 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (aa239-506, Biotin) - LS-C301050 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (HRP) - LS-C317564 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody - LS-C310840 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (FITC) - LS-C317565 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody - LS-C317567 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (clone 2D9) - LS-C179427 from LifeSpan Bioscience Prices $370.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone 2D9

Anti-KPNA1 / Importin Alpha 5 Antibody (Biotin) - LS-C318915 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KPNA1 / Importin Alpha 5 Antibody (aa1-539, Azide-free) - LS-C327695 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

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