| Gene Symbol | KPNA1 |
|---|---|
| Entrez Gene | 3836 |
| Alt Symbol | IPOA5, NPI-1, RCH2, SRP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | karyopherin alpha 1 (importin alpha 5) |
| Other Description | RAG cohort protein 2|SRP1-beta|importin alpha 5|importin subunit alpha-1|importin subunit alpha-5|importin-alpha-S1|karyopherin subunit alpha-1|nucleoprotein interactor 1|recombination activating gene cohort 2 |
| Swissprots | Q6IBQ9 D3DN93 P52294 Q9BQ56 |
| Accessions | CCQ43172 EAW79482 EAW79483 P52294 AA689229 AF035311 AI216375 AK125626 BAG54224 AK128280 BAG54654 AK299030 BAG61106 AK312713 AL700464 AL710311 BC002374 AAH02374 BC003009 AAH03009 BC029937 BC090864 AAH90864 BG287593 BT006959 AAP35605 CA433573 CR456743 CAG33024 DA308391 DN991078 DQ891406 ABM82332 DQ896822 ABM87821 S75295 AAC60648 U20620 XM_005247437 XP_005247494 XM_005247439 XP_005247496 XM_011512795 XP_011511097 XM_011512796 XP_011511098 XM_011512797 XP_011511099 NM_002264 NP_002255 NR_026698 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}. |
| Tissue Specificity | Expressed ubiquitously. |
| Top Pathways | Influenza A |