KPNA1

Gene Symbol	KPNA1
Entrez Gene	3836
Alt Symbol	IPOA5, NPI-1, RCH2, SRP1
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 1 (importin alpha 5)
Other Description	RAG cohort protein 2|SRP1-beta|importin alpha 5|importin subunit alpha-1|importin subunit alpha-5|importin-alpha-S1|karyopherin subunit alpha-1|nucleoprotein interactor 1|recombination activating gene cohort 2
Swissprots	Q6IBQ9 D3DN93 P52294 Q9BQ56
Accessions	CCQ43172 EAW79482 EAW79483 P52294 AA689229 AF035311 AI216375 AK125626 BAG54224 AK128280 BAG54654 AK299030 BAG61106 AK312713 AL700464 AL710311 BC002374 AAH02374 BC003009 AAH03009 BC029937 BC090864 AAH90864 BG287593 BT006959 AAP35605 CA433573 CR456743 CAG33024 DA308391 DN991078 DQ891406 ABM82332 DQ896822 ABM87821 S75295 AAC60648 U20620 XM_005247437 XP_005247494 XM_005247439 XP_005247496 XM_011512795 XP_011511097 XM_011512796 XP_011511098 XM_011512797 XP_011511099 NM_002264 NP_002255 NR_026698
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SRP1 full length protein - ab114791 from Abcam Category Protein Source Wheat germ Species Human

Human SRP1 peptide - ab23141 from Abcam Category Peptide Species Human

KPNA1 / Importin Alpha 5 Antibody Blocking Peptide - LS-E19697 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNA1 / Importin Alpha 5 Antibody Blocking Peptide - LS-E19698 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNA1 / Importin Alpha 5 Antibody Blocking Peptide - LS-E25662 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNA1 / Importin Alpha 5 Antibody Blocking Peptide - LS-E31002 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Importin alpha 5/KPNA1/SRP1 Protein - H00003836-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Importin alpha 5/KPNA1/SRP1 Blocking Peptide - NBP1-76297PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

KPNA1-Antibody-N-term-Blocking-Peptide - BP14416a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRP1 blocking peptide - GTX26035-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human Karyopherin Alpha 1 Protein - abx067599 from Abbexa Category Protein Source E.coli Species Human

SRP1 Peptide - AC21-0492-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KPNA1 / Importin alpha-1 - H00003836-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KPNA1 / Importin alpha-1 - H00003836-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KPNA1 / Importin alpha-1 control peptide - AP26273CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Karyopherin Alpha 1 (KPNa1), Human - 20-8977 from ARP American Research Products Category Protein Prices $497.00 Sizes 50 µg Source E.coli Species Human

KPNA1 Peptide - 45-811P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

KPNA1 Peptide - 5981P from ProSci Category Peptide Species Human

KPNA1 fusion protein - Ag12751 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human KPNA1 - KPNA1-31462TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Karyopherin Alpha 1 (KPNa1) - RPE747Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Karyopherin Alpha 1 (KPNa1) - RPE747Hu01 from Cloud-clone Category Protein Source E.coli Species Human

KPNA1 / Importin alpha-1 (transcript variant 1) - TP310333 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

KPNA1/Importin alpha 5, Peptide - MBS425018 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

Importin alpha 5/KPNA1/SRP1 Recombinant Protein Antigen - NBP2-47418PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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