Gene Symbol | LAX1 |
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Entrez Gene | 54900 |
Alt Symbol | LAX |
Species | Human |
Gene Type | protein-coding |
Description | lymphocyte transmembrane adaptor 1 |
Other Description | LAT-like membrane associated protein|linker for activation of x cells|lymphocyte transmembrane adapter 1|membrane-associated adapter protein LAX |
Swissprots | Q6NSZ6 Q9NXB4 Q8IWV1 J3KP69 B7Z744 |
Accessions | EAW91489 EAW91490 EAW91491 Q8IWV1 AK000347 BAA91101 AK225331 AK301076 BAG62682 AK301421 BAH13480 AY090784 AAM09818 BC069650 AAH69650 BC089408 AAH89408 DC414389 XM_006711397 XP_006711460 NM_001136190 NP_001129662 NM_001282878 NP_001269807 NM_017773 NP_060243 |
Function | Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. {ECO:0000269|PubMed:12359715}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12359715}; Single-pass type III membrane protein {ECO:0000269|PubMed:12359715}. |
Tissue Specificity | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. {ECO:0000269|PubMed:12359715}. |
LAX1 CRISPR/Cas9 KO Plasmid (h) - sc-409443 from Santa Cruz Biotechnology
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LAX1 HDR Plasmid (h) - sc-409443-HDR from Santa Cruz Biotechnology
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LAX1 Double Nickase Plasmid (h) - sc-409443-NIC from Santa Cruz Biotechnology
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LAX1 Double Nickase Plasmid (h2) - sc-409443-NIC-2 from Santa Cruz Biotechnology
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LAX1 CRISPR Activation Plasmid (h) - sc-409443-ACT from Santa Cruz Biotechnology
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LAX1 CRISPR Activation Plasmid (h2) - sc-409443-ACT-2 from Santa Cruz Biotechnology
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LAX1 Lentiviral Activation Particles (h) - sc-409443-LAC from Santa Cruz Biotechnology
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LAX1 Lentiviral Activation Particles (h2) - sc-409443-LAC-2 from Santa Cruz Biotechnology
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LAX1 siRNA (h) - sc-88833 from Santa Cruz Biotechnology
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LAX1 shRNA Plasmid (h) - sc-88833-SH from Santa Cruz Biotechnology
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LAX1 shRNA (h) Lentiviral Particles - sc-88833-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11570 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11570 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09937 from Sigma-Aldrich
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LAX1 siRNA (Human) - CRJ0309 from Cohesion Biosciences
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shRNA set against Human LAX1 (NM_017773.3) - SHH328703 from Creative biogene
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Human LAX1 siRNA - orb270810 from Biorbyt
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LAX1 shRNA Plasmid (Human) - CHJ0309 from Cohesion Biosciences
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LAX1 miRNA 3'UTR clone - MiUTR3H-15294 from Creative biogene
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LAX1 miRNA 3'UTR clone - MiUTR3H-15295 from Creative biogene
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