LAX1

Gene Symbol LAX1
Entrez Gene 54900
Alt Symbol LAX
Species Human
Gene Type protein-coding
Description lymphocyte transmembrane adaptor 1
Other Description LAT-like membrane associated protein|linker for activation of x cells|lymphocyte transmembrane adapter 1|membrane-associated adapter protein LAX
Swissprots Q6NSZ6 Q9NXB4 Q8IWV1 J3KP69 B7Z744
Accessions EAW91489 EAW91490 EAW91491 Q8IWV1 AK000347 BAA91101 AK225331 AK301076 BAG62682 AK301421 BAH13480 AY090784 AAM09818 BC069650 AAH69650 BC089408 AAH89408 DC414389 XM_006711397 XP_006711460 NM_001136190 NP_001129662 NM_001282878 NP_001269807 NM_017773 NP_060243
Function Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. {ECO:0000269|PubMed:12359715}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12359715}; Single-pass type III membrane protein {ECO:0000269|PubMed:12359715}.
Tissue Specificity Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. {ECO:0000269|PubMed:12359715}.

LAX1 (D-15) - sc-161786 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LAX1 (S-14) - sc-161789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LAX1 (S-14): sc-161789. Western blot analysis of LAX1 expression in Jurkat (A) and HeLa (B) whole cell lysates and rat brain tissue extract (C).

Anti-LAX1 antibody - ab154491 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LAX1 antibody (ab154491) at 1/500 dilution + NT2D1 whole cell lysate at 30 µg

Anti-LAX1 antibody - ab82785 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LAX1 antibody (ab82785) at 1 µg/ml + HeLa cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/5000 dilution

Anti-LAX1 antibody - ab69327 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-LAX1 antibody (ab69327) at 1/500 dilutionLane 1 : LAX1 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilutiondeveloped using the ECL technique

Anti-LAX1 antibody [EP8753] - ab133759 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP8753
Immunohistochemical analysis of paraffin embedded Human spleen tissue labelling LAX1 with ab133759 at 1/100.

Anti-LAX1 antibody - C-terminal - ab138601 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-LAX1 antibody - C-terminal (ab138601) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-LAX1 / LAX Antibody (aa136-398) - LS-C71553 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa62-73) - LS-C87199 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa150-163) - LS-C112899 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa369-398, Biotin) - LS-C237034 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa369-398, AP) - LS-C237033 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa369-398, APC) - LS-C237035 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa369-398, FITC) - LS-C237036 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa369-398, Azide-free, HRP) - LS-C248691 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa216-265) - LS-C81030 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-LAX1 / LAX Antibody - LS-C308723 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa369-398, PE) - LS-C237037 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (aa368-398) - LS-C322596 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LAX1 / LAX Antibody (C-Terminus) - LS-C116903 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LAX1 antibody LS-C116903 Western blot of Jurkat lysate.

Anti-LAX1 / LAX Antibody (aa369-398) - LS-C160033 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LAX1 Antibody western blot of K562 cell line lysates (35 ug/lane). The LAX1 antibody detected the LAX1 protein (arrow).

Anti-LAX1 / LAX Antibody - LS-C332576 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cell line, using LAX1 antibody.

Anti-LAX1 / LAX Antibody (aa348-398) - LS-C291094 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human LAX by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using RIPA buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-LAX antibody used for IP at 6 ug per reaction. LAX was also immunoprecipitated by rabbit anti-LAX antibody BL16833. For blotting immunoprecipitated LAX, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-LAX1 / LAX Antibody (Extracellular Domain, clone EP8753) - LS-C154672 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP8753
IHC of paraffin-embedded human spleen tissue using anti-LAX1 antibody.

LAX1 Antibody - AF4706 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of Jurkat human acute T cell leukemia cell line and K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human LAX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4706) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for LAX1 at approximately 70 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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